Non invasive temperature measurement for brain tumor

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We have developed target liposome for malignant brain tumor. This liposome contained MR enhanced materials which identify the distribution area of chemotherapy drugs under the MR imaging.A noninvasive method to evaluate intracranial pressure (ICP) and brain tissue compliance based on magnetic resonance (MR) imaging was proposed.Brain circulations, blood and cerebrospinal fluid (CSF) flows, was devised. The input for the inverse analysis was the CSF flow rate obtained by phase contrast MR velocity imaging, whereas the estimation function was the square error of the estimated arterial blood flow rate. Experiments using a brain-circulation-mimicking phantom followed by numerical simulations confirmed that the proposed technique yielded relative indices of the compliance and pressure. Studies on 25 healthy (22-63 years old) and 9 patient (27-69 years old) volunteers revealed that the healthy and patient groups distributed in significantly different regions in a two-dimensional space formed space formed by the indices of tissue compliance and intracranial pressure, demonstrating the feasibility and viability of the proposed technique for classifying the statuses of the intracranial biomechanical properties of the subjects.