Study on the Molecular Assembly Using Cholic Acid

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1)Molecular recognition by tripodant cholic acid derivatives : Tripodants prepared from three molecules of cholic acids with trimesic and cyclotriverahylene were investigated for recognition of deoxyribonucleosides and AZT The largest binding constant (5 x 10^5 M^<-1>) was obtained for dA using a methyl cholate tether in solid -liquid extraction. Weak binding (10^2 M^<-1>) was observed for AZT.2)X-ray structural determination of a bicyclocholaphane : X-ray structure of macrocycles containing steroidal moiety has hardly been reported. We succeeded to determined the X-ray structure of bicyclocholaphane which possessed P-helicity in its crystal structure, the cholic acid pillars were twisted., while it had two twisted diastereomeric forms in solution.3)Trial to prepare liquid crystalline cholic acid derivatives : In order to prepare dimeric type of liquid crystalline molecules of cholic acid derivatives, various kinds of cholate possessing long aryl and alkyl chains were prepared. Unlike cholesterol which is a flat steroid, we expected to have unique liquid crystalline properties from the L-shaped bent type steroids. However, they did not show liquid crystal phases yet.4)Preparation of a liquid crystalline molecule for molecular recognition: Self-assembled liquid crystal phases were prepared from homooxacalic[4]arene derivatives Its core part may behave as a potential molecular recognition site.