Fungal Morphogenesis and Growth Polarity

真菌形态发生和生长极性

• 批准号: 5333290
• 负责人: Privatdozent Dr. Stephan Seiler
• 金额: --
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2001
• 资助国家: 德国
• 起止时间: 2000-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5333290?language=en
• 关键词: Fungal; Morphogenesis; Growth; Polarity

The long term goal of this research proposal is to understand the spacial and temporal signals in the filamentous fungus Neurospora crassa that lead to the establishment and maintenance of polar growth and regulation of the position of new tips during the formation of side branches. As a basis to study cellular development in a filamentous fungus we have isolated a large collection ( 100 complementation groups) of temperaturesensitive mutants defective in the maintenance and regulation of growth polarity. Cloning and sequencing genes required for normal growth will provide a molecular starting point and will be essential for the understanding of this fascinating phenomenon. The next step will be the characterisation of the functions of the identified proteins to obtain a molecular description of the mechanisms involved in cell morphogenesis. Gaining insight into fungal morphogenesis will have important consequences for understanding the mechanisms controlling the growth of higher eukaryotic cells as a high degree of evolutionary conservation can be anticipated. Furthermore, this information will help us to understand the mechanisms contributing to fungal pathogenesis and the industrial production of proteins.

这项研究的长期目标是了解丝状真菌粗糙脉孢菌中的空间和时间信号，这些信号导致极性生长的建立和维持以及侧枝形成过程中新尖端位置的调节。作为研究丝状真菌细胞发育的基础，我们已经分离出大量的（100个互补组）在生长极性的维持和调节中有缺陷的温度敏感突变体。克隆和测序正常生长所需的基因将提供一个分子起点，对于理解这一迷人现象至关重要。下一步将是鉴定蛋白质的功能，以获得细胞形态发生机制的分子描述。深入了解真菌的形态发生将有重要的后果，了解控制高等真核细胞生长的机制，因为可以预见到高度的进化保守性。此外，这些信息将有助于我们了解真菌致病机制和蛋白质的工业生产。