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Development of a new ultrasound system for stroke and cardiac infarction therapy

开发用于中风和心肌梗塞治疗的新型超声系统

基本信息

批准号：
15300187
负责人：
TACHIBANA Katsuro
金额：
$ 9.66万
依托单位：
Fukuoka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300187/
关键词：
ultrasound thrombolysis miniature ultrasound probe frequency 血栓溶解

项目摘要

The object of this research project is to develop a miniature ceramic ultrasound element tipped catheter device which can be inserted inside a blood vessel. This device can be used to dissolve clot or accelerate thrombolysis. The non-invasiveness and safety was evaluated in correlation with intensity of ultrasound energy. The use of microbubble was also evaluated if there was an enhancing effect on the acceleration of thrombolysis. A total of 4 different types of PZT ultrasound elements were used, 1)1mm diameter cylinder shaped(Fujicera), 1MHz drive vibrating portion was isolated with a special coating, (maximum electrical voltage was 100 Vpp). 2)6 mm and 8 mm diameter disk type (2mm thickness, 2MHz), 3)20 mm diameter disk type high intensity ultrasound probe. Each of these probes were inserted into a specially built acoustic tank with degassed water. The power input into each probe was measured by a specifically designed high speed current detector and quantified. The ultrasound pressure was measured by a newly developed microbubble collapse visualization method and analyzed with computer. The duty ratio of 10%, burst rate of 10Hz was produce as baseline acoustic condition. Chandler Loop Method artificial thrombus was most accelerated by microbubbles (ultrasound contrast agent) Levovist and Optison combination. The 20 mm diameter element produce the most enhancing effect.

本课题的研究目标是研制一种微型陶瓷超声元件尖端导管装置，该装置可插入血管内。该装置可用于溶解凝块或加速溶栓。以超声能量强度评价其无创性和安全性。微泡的使用也被评估是否对加速溶栓有增强作用。共使用4种不同型号的PZT超声元件，1)直径1mm圆柱形（Fujicera）， 1MHz驱动振动部分用特殊涂层隔离，（最高电压为100 Vpp）。2) 6mm和8mm直径盘型（2mm厚度，2MHz）， 3) 20mm直径盘型高强度超声探头。每个探针都被插入一个装有脱气水的特制声学水箱中。每个探头的输入功率由专门设计的高速电流检测器测量并量化。采用新开发的微泡崩塌可视化方法测量超声压力，并进行计算机分析。基准声学条件为占空比为10%，突发频率为10Hz。微泡（超声造影剂）、Levovist和Optison联合使用对人工血栓的加速作用最大。直径20毫米的元件增强效果最好。