Early detection and management of coronary atherosclerosis by O-15 water PET

O-15 水 PET 早期检测和治疗冠状动脉粥样硬化

• 批准号: 15390354
• 负责人: TAMAKI Nagara
• 金额: $ 9.22万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390354/
• 关键词: emission tomography; blood flow; coronary artery disease; myocardium; endothelial function

Assessment of coronary atherosclerosis plays a major role for dearly detection and management of patients with coronary artery disease. Positron emission tomography (PET) using O-15 labeled water permits quantitative assessment of myocardial blood flow, and therefore, this is valuable means for measurement of myocardial flow reserve and coronary endothelial function noninvasively. In the study of patients suspected with coronary artery disease, myocardial flow reserve was reduced not only in the areas with coronary stenosis but also in the remote areas in the patients having coronary risk factors. Multivariate analysis indicated that smoking and diabetes were the only independent variables which reduced myocardial flow reserve. In addition, coronary endothelial dysfunction was identified in patients with young healthy smokers and remote stage of Kawasaki disease. Moreover, such coronary endothelial dysfunction was reversible after smoking cessation. These data indicate that O-15 labeled water PET is feasible for early detection and management of coronary atherosclerosis in clinical setting.

冠状动脉粥样硬化的评估对冠状动脉疾病的诊断和治疗具有重要意义。使用O-15标记水的正电子发射断层扫描（PET）可以定量评估心肌血流，因此，这是无创测量心肌血流储备和冠状动脉内皮功能的有价值的手段。在疑似冠状动脉疾病患者的研究中，存在冠状动脉危险因素的患者，心肌血流储备不仅在冠状动脉狭窄区减少，而且在偏远地区也有所减少。多因素分析表明，吸烟和糖尿病是唯一降低心肌血流储备的自变量。此外，在年轻健康吸烟者和川崎病晚期患者中发现冠状动脉内皮功能障碍。此外，这种冠状动脉内皮功能障碍在戒烟后是可逆的。这些数据表明，O-15标记水PET在临床上用于冠状动脉粥样硬化的早期检测和治疗是可行的。

项目成果

Improvement of algorithm for quantification of regional myocardial blood flow using ^<15>O-water with PET.

使用^ 15 O-水和PET对局部心肌血流进行量化的算法的改进。

• 发表时间: 2004
• 期刊: J Nucl Med 45(11)
• 作者: Sasaki T.;Iwamoto A.;Tsuboi H.;Watanabe Y.;Katoh C
• 通讯作者: Katoh C

Reduced oxidative metabolic response in dysfunctional myocardium with preserved glucose metabolism but with impaired contractile reserve.

功能障碍心肌中氧化代谢反应减少，葡萄糖代谢得以保留，但收缩储备受损。

• 发表时间: 2004
• 期刊: J Nucl Med 45(11)
• 作者: Sasaki T.;Iwamoto A.;Tsuboi H.;Watanabe Y.;Katoh C;Yoshinaga K
• 通讯作者: Yoshinaga K

Quantitative assessment of regional myocardial flow reserve using Tc-99m-sestamibi imaging

使用 Tc-99m-sestamibi 成像定量评估局部心肌血流储备

• 发表时间: 2005
• 期刊: Circulation J 69(2)
• 作者: Kageyama H;Morita K;Katoh C;Tsukamoto T;Noriyasu K;Mabuchi M;Naya M;Kawai Y;Tamaki N;Kageyama H;Tsukamoto T
• 通讯作者: Tsukamoto T

Tadamura E: "The effect of nitroglycerin on myocardial blood flow in various segments characterized by rest-redistribution thallium SPECT"J Nucl Med. 44(5). 745-751 (2003)

Tadamura E：“硝酸甘油对以静止再分布铊 SPECT 为特征的各节段心肌血流的影响”J Nucl Med。

Quantitative assessment of regional myocardial flow reserve using Tc-99m-sestamibi imaging.

使用 Tc-99m-sestamibi 成像定量评估局部心肌血流储备。

• 发表时间: 2005
• 期刊: Circulation.J. 69(2)
• 作者: Tsukamoto T;Ito Y;Noriyasu K;Morita K;Katoh C;Okamoto H;Tamaki N
• 通讯作者: Tamaki N