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QUANTITATIVE ANALYSIS OF MYOCARDIAL PERFUSION AND METABOLISM USING SPECT

使用 SPECT 对心肌灌注和代谢进行定量分析

基本信息

批准号：
08407023
负责人：
TAMAKI Nagara
金额：
$ 20.93万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08407023/
关键词：
emission tomography myocardium myocardial blood flow metabolism 1-123 BMIPP Tc-99m sestamibi Tc-99m sestsmibi myocardial blood-flow Emission Tomography Tc-99m Sestamibi Myocardium Myocardial Blood Flow

项目摘要

1.A new workstation with a recently developed algorithm was installed to perform three-dimensional image co-registration of SPECT images with other anatomical images using CT or MRI.This image co-registration was useful to differentiate actual hypoperfusion from the artifacts due to partial volume effect on the brain SPECT studies. Such image fusion analysis is considered to be valuable for precise evaluation of myocardial perfusion and function in various cardiac diseases.2. ECG-gated myocardial perfusion SPECT has recently been applied for simultaneous evaluation of regional perfusion and function. This new technique was valuable for assessing pathophysiology in patients with complete left bundle branch block and risk stratification in patients suspected with coronary artery disease.3. Assessment of regional myocardial metabolism in vivo has been performed with use of iodinated fatty acid compound, BMIPP.In the follow-up study of patients with acute myocardial infarction, the perfusion SPECT was applied to estimate the area at risk, infarcted myocardium, and salvaged myocardium. Since metabolic recovery was slower than the perfusion recovery after revascularization therapy, BMIPP-SPECT at one week after infarction was valuable for estimating the area at risk. Furthermore, BMIPP imaging was used for identifying metabolic abnormalities in hypertrophic myocardium in the spontaneous hypertensive rat model and patients with hypertrophic cardiomyopathy. Metabolic alterations preceded perfusion abnormalities in these myocardial disorders. Thus, the combined imaging of perfusion and metabolism with SPECT may provide insight in to pathophysiology in various myocardial disorders.

1.安装了采用最近开发的算法的新工作站，使用 CT 或 MRI 对 SPECT 图像与其他解剖图像进行三维图像联合配准。这种图像联合配准有助于区分实际的灌注不足和由于脑部 SPECT 研究的部分体积效应而产生的伪影。这种图像融合分析被认为对于精确评估各种心脏疾病的心肌灌注和功能具有重要价值。 2．心电门控心肌灌注 SPECT 最近已应用于局部灌注和功能的同步评估。这项新技术对于评估完全性左束支传导阻滞患者的病理生理学以及疑似冠心病患者的危险分层具有重要价值。 3．使用碘化脂肪酸化合物BMIPP对体内局部心肌代谢进行评估。在急性心肌梗死患者的随访研究中，应用灌注SPECT评估危险区域、梗塞心肌和挽救心肌。由于血运重建治疗后代谢恢复慢于灌注恢复，因此梗塞后 1 周的 BMIPP-SPECT 对于估计危险区域很有价值。此外，BMIPP 成像还用于识别自发性高血压大鼠模型和肥厚型心肌病患者肥厚心肌的代谢异常。在这些心肌疾病中，代谢改变先于灌注异常。因此，利用 SPECT 进行灌注和代谢的联合成像可以深入了解各种心肌疾病的病理生理学。