Radionuclide imaging for tissue characterization and treatment effect of experimental atherosclerosis

放射性核素成像用于实验性动脉粥样硬化的组织表征和治疗效果

• 批准号: 20390321
• 负责人: TAMAKI Nagara
• 金额: $ 11.98万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390321/
• 关键词: 動脈硬化; 不安定プラーク; 核医学診断; エミッショントモグラフィ; デオキシグルコース; アポトーシス; 核医学

In order to assess atheroma vulnerability, we have selected two radiopharmaceuticals to probe atheroma imaging in vivo using apolipoprotein E knockout (apoE-/-) mice. The uptakes of FDG and Annexin A5 were quantitatively measured on autoradiography to compare with various parameters on histological and immunohistochemical staining. These uptakes were closely correlated with atheroma staging and macrophage infiltration. The current study indicated that the radionuclide imaging has a potential to identify atheroma vulnerability.

为了评估动脉粥样硬化的脆弱性，我们选择了两种放射性药物来探测动脉粥样硬化成像在体内使用载脂蛋白E基因敲除（apoE-/-）小鼠。放射自显影定量测定FDG和Annexin A5的摄取，并与组织学和免疫组化染色的各种参数进行比较。这些摄取与动脉粥样硬化分期和巨噬细胞浸润密切相关。目前的研究表明，放射性核素显像有可能识别动脉粥样硬化的脆弱性。

项目成果

Localization of Deoxyglucose and Annexin A5 in Experimental Atheroma Correlates with Macrophage Infiltration but not Lipid Deposition in the Lesion

• DOI: 10.1007/s11307-010-0389-7
• 发表时间: 2011-08-01
• 期刊: MOLECULAR IMAGING AND BIOLOGY
• 影响因子: 3.1
• 作者: Zhao, Yan;Zhao, Songji;Tamaki, Nagara
• 通讯作者: Tamaki, Nagara

Molecular Imaging of Apoptosis with Radio-Labeled Annexin A5 Focused on the Evaluation of Tumor Response to Chemotherapy

• DOI: 10.2174/187152009789377736
• 发表时间: 2009-11-01
• 期刊: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
• 影响因子: 2.8
• 作者: Kuge, Yuji;Zhao, Songji;Tamaki, Nagara
• 通讯作者: Tamaki, Nagara

Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET

使用发生器产生的 82Rb PET 定量分析冠状动脉内皮功能：与 15O 标记的水 PET 比较

• DOI: 10.1007/s00259-010-1541-y
• 发表时间: 2010
• 期刊: European Journal of Nuclear Medicine and Molecular Imaging
• 影响因子: 9.1
• 作者: K. Yoshinaga;O. Manabe;C. Katoh;Li Chen;R. Klein;M. Naya;R. deKemp;K. Williams;R. Beanlands;N. Tamaki
• 通讯作者: N. Tamaki

Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-Annexin A5 Uptake in Apolipoprotein E-Deficient and Wild-Type C57BL/6J Mice

• DOI: 10.2967/jnumed.108.051847
• 发表时间: 2008-10-01
• 期刊: JOURNAL OF NUCLEAR MEDICINE
• 影响因子: 9.3
• 作者: Zhao, Yan;Kuge, Yuji;Tamaki, Nagara
• 通讯作者: Tamaki, Nagara

Myocardial imaging with ^<18>F-fluoro-2-deoxygluose positron emission tomography and magnetic resonance imaging in sarcoidosis.

使用18 F-氟-2-脱氧葡萄糖正电子发射断层扫描和磁共振成像对结节病进行心肌成像。

• 发表时间: 2008
• 期刊: Eur J Nucl Med Mol Imaging 35(5)
• 作者: Ohira H;Tsujino I;Ishimura S;Oyama N;Takei T;Tsukamoto E;Miura M;Sakaue S;Tamaki N;Nishimura M
• 通讯作者: Nishimura M