Radionuclide imaging for tissue characterization and treatment effect of experimental atherosclerosis

为了评估动脉粥样硬化的易感性，我们选择了两种放射性药物来探测使用载脂蛋白E基因敲除(apoE-/-)小鼠的体内动脉粥样硬化成像。在放射自显影上定量测量FDG和Annexin A5的摄取，并与组织学和免疫组织化学染色的各项参数进行比较。这些摄取与动脉粥样硬化分期和巨噬细胞浸润密切相关。目前的研究表明，放射性核素成像具有识别动脉粥样硬化易损性的潜力。

In order to assess atheroma vulnerability, we have selected two radiopharmaceuticals to probe atheroma imaging in vivo using apolipoprotein E knockout (apoE-/-) mice. The uptakes of FDG and Annexin A5 were quantitatively measured on autoradiography to compare with various parameters on histological and immunohistochemical staining. These uptakes were closely correlated with atheroma staging and macrophage infiltration. The current study indicated that the radionuclide imaging has a potential to identify atheroma vulnerability.