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Early Diagnosis System of Cartilage Degeneration by Ultrasound

超声软骨退变早期诊断系统

基本信息

批准号：
15390457
负责人：
IKEUCHI Ken
金额：
$ 4.03万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

1.Ultrasonic system was established to measure articular cartilage using wavelet transform of reflected wave.2.It is found that strength of reflected wave indicates dynamic stiffness while endurance time indicates damage in the cartilage by simultaneous measurements of dynamic stiffness, density, sound velocity and defects in the cartilage.3.It is found that dynamic stiffness, sound velocity and density reduce with a development of degeneration. Thereafter, endurance time of the reflected wave increases and internal reflection appears.4.It is confirmed by experiment with articular cartilage specimens degenerated by use of collagenase enzyme that maximum strength of the reflected wave decreases with a development of degeneration.5.By means of ultrasonic measurement for unstable rabbit knee model by cutting of ligaments and meniscus and for degenerated cartilage model by collagenase treatment, cartilage at medial femoral chondyle degenerates at first and then degeneration appears at lateral femoral chondyle.6.In addition to the transducer of piezo-electric ceramic, transducer of piezo-electric polymer was produced. Both types were prove applicable to diagnoses of knee joint, hip joint, finger joint and vertebra.7.Cartilage surface of transplanted bone-cartilage complex was measured. It is found that regenerated cartilage after transplantation survives during daily life though its dynamic stiffness is lower than the original cartilage.8.Dynamic stiffness of rabbit knee articular cartilage cultured in vitro was significantly lower than the original cartilage.9.Rabbit knee articular cartilages regenerated by means of several regeneration therapies were measured and compared. According to the result, bone marrows induced to the defect by drilling and chondrocytes injected to scaffold produced cartilage with high dynamic stiffness.

1.建立了基于反射波小波变换的关节软骨超声检测系统。2.通过同时测量软骨的动态刚度、密度、声速和软骨中的缺陷，发现反射波的强度代表软骨的动态刚度，而持续时间代表软骨的损伤。3.发现动态刚度、声速和密度随着退变的发展而减小。4.通过对胶原酶变性关节软骨标本的实验证实，随着退变的发展，反射波的最大强度降低。5.对不稳定的兔膝关节韧带和半月板切割模型和胶原酶处理的退变软骨模型进行超声测量，发现股骨内侧软骨先退化，后退变。这两种类型均适用于膝关节、髋关节、手指关节和椎骨的诊断。7.测量移植骨-软骨复合体的骨面。结果表明，兔膝关节软骨移植后，虽然其动态刚度低于原始软骨，但仍能在日常生活中存活。8.体外培养的兔膝关节软骨的动态刚度明显低于原始软骨。结果表明，经钻孔诱导后的骨髓和植入支架内的软骨细胞形成了具有较高动态刚度的软骨。