Control of Biodegradation in vivo and Clinical Application for the Inhibition of Degradation

体内生物降解的控制和抑制降解的临床应用

• 批准号: 15390573
• 负责人: SANO Hidehiko
• 金额: $ 8.38万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390573/
• 关键词: Adhesion; Degradation; 歯質接着; バイオデグラデーション; MMP; 象牙質接着; 樹脂含浸層; 超微細構造

Degradation of resin/dentin bonds was caused by the gradual loss of the resinous material and enzymatic attack to dential collagen fibrils. This phenomenon was observed both in vivo and in vitro. Among the enzymes, MMP was the main enzyme to degrade collagen fibrils.Some inhibitors were effective to the inhibition of the degradation such as CHX and ZnCl_2. Other possible solution for protecting resin/dentin interface should be creation of Nano-interaction zone.

树脂/牙本质键的降解是由于牙本质材料的逐渐丧失和酶对牙本质胶原纤维的攻击造成的。在体内和体外都观察到这种现象。其中MMP是降解胶原纤维的主要酶，CHX、ZnCl_2等抑制剂对MMP的降解有抑制作用。保护树脂/牙本质界面的其他可能的解决方案应该是创建纳米相互作用区。

项目成果

In vivo degradation of resin-dentin bonds produced by a self-etch and an etch-and-rinse adhesive

• DOI: 10.1111/j.1600-0722.2005.00222.x
• 发表时间: 2005-08-01
• 期刊: EUROPEAN JOURNAL OF ORAL SCIENCES
• 影响因子: 1.9
• 作者: Koshiro, K;Inoue, S;Van Meerbeek, B
• 通讯作者: Van Meerbeek, B