An International Collaborative Study to investigate Genetic Susceptibility for chronic Kidney Disease Which is Common in Asian

一项国际合作研究，调查亚洲常见慢性肾病的遗传易感性

• 批准号: 15406033
• 负责人: DOI Toshio
• 金额: $ 8.58万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15406033/
• 关键词: Kidney; Renal failure; Hemodialysis; IgA nephropathy; complex trait disease; 日中共同研究; 慢性腎炎; 遺伝子変異

Glomerulonephritis is the leading cause of end stage renal disease worldwide. Both genetic and environmental factors contribute to disease susceptibility and elucidation of such predisposing factors to is particularly important for development of better treatment and prevention. Immunoglobulin A nephropathy is an immune-complex-mediated glomerulonephritis, in which a remarkable ethnic difference in disease frequency have been reported : it is more common in Asian than in Black and Caucasian. This study is aimed to disclose the genetic predisposing factor for IgA nephropathy that may be prevalent in the Asian population. The clinical, pathological, and genetic features of familial IgA nephropathy were investigated as international collaborative study between Japan and general hospital of PLA, Beijing, China. Database of a large cohort of patients accumulated from multiple institutions. Environmental risk factor exposure data were collected from participants. A gemome-wide linkage analysis and family-based association study is now being conducted. The study should advance our understanding of the etiology of chronic kidney disease and stimulate academic interaction among Asian nephrologists.

肾小球肾炎是世界范围内终末期肾病的主要原因。遗传和环境因素都有助于疾病的易感性，阐明这些易感因素对于更好地治疗和预防尤为重要。免疫球蛋白A肾病是一种免疫复合体介导的肾小球肾炎，其发病频率存在显著的种族差异：在亚洲人中比黑人和高加索人更常见。这项研究旨在揭示可能在亚洲人群中流行的IgA肾病的遗传易感因素。通过日本与解放军总医院、北京、中国的国际合作研究，对家族性IgA肾病的临床、病理和遗传学特征进行了研究。从多个机构积累的大量患者队列的数据库。环境风险因素暴露数据是从参与者那里收集的。目前正在进行一项全基因组的连锁分析和以家庭为基础的关联研究。这项研究将促进我们对慢性肾脏疾病病因的理解，并促进亚洲肾病学家之间的学术互动。

项目成果

A familial childhood-onset relapsing nephrotic syndrome

• DOI: 10.1038/sj.ki.5002110
• 发表时间: 2007-05-01
• 期刊: KIDNEY INTERNATIONAL
• 影响因子: 19.6
• 作者: Kitamura, A.;Tsukaguchi, H.;Iijima, K.
• 通讯作者: Iijima, K.

Raft-Dependent Endocytic Pathway of Nephrin Down-regulates Its Signal Transduction Through interaction with Src-Family Kinase Fyn.

Nephrin 的筏依赖性内吞途径通过与 Src 家族激酶 Fyn 相互作用下调其信号转导。

• 发表时间: 2005
• 期刊: J Am Soc Nephrol 16
• 作者: Shono A;Tsukaguchi H;X-S Qin;Doi T.
• 通讯作者: Doi T.

ネフローゼ症候群の責任遺伝子の探索、研究方法と動向

寻找肾病综合征相关基因、研究方法和趋势

• 发表时间: 2005
• 期刊: 腎と透析 59
• 作者: 塚口 裕康;飯島一誠
• 通讯作者: 飯島一誠

A genetic mapping for a familial nephropathy.

家族性肾病的基因图谱。

• 发表时间: 2004
• 期刊: Nephrology 9
• 作者: Mitoma H;Horiuchi T;et al.;Kohei Ueda et al.;Ishihara H et al.;谷澤 幸生(分担執筆);Tsukaguchi H.
• 通讯作者: Tsukaguchi H.

Shono A: "An Adhesion Molecule Coxsackievirus and Adenovirus Receptor (CAR) is a Novel Binding Partner of Podocin"J Am Soc Nephrol. 14. 25A (2003)

Shono A：“柯萨奇病毒和腺病毒受体 (CAR) 的粘附分子是 Podocin 的新型结合伙伴”J Am Soc Nephrol。