Investigation for progressive factors of glomerulosclerosis.

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Glomerulosclerosis is the most important leading to end-stage kidney disease. The mechanism leading to mesangial cell proleferation and phenotypic change is responsible for the subsequent development of glomeruloscierosis. However, the precise mechanism for glomerular injuries is not completely understood. A novel DNA binding protein (MSW) for type IV collagen gene has a multiple functions including large subunit of DNA replication factor C and DNA binding for angiotensinogen and pro-piomelanocortin corticotropin releasing factor. We found that MSW is a transcription factor, which regulates type IV collagen gene and that MSW is a important modulator in a smooth muscle phenotypic change of mesangial cells. The regulation of the gene expression is associated with translocation of MSW from nucleus to cytoplasm. We found that transforming growth factor-β is an important modulator for the translocation of MSW, which eventually regulates the gene expression. These results indicate that MSW protein plays an important role in regulation of smooth muscle phenotype and may contribute to glomerular cell proliferation and the development of glomerulosclerosis.