High Pressure and Fluorous Approaches to Fostriecin Libraries: New Therapeutic Opportunities.

天然产物Fostriecin通过一种新的机制显示出相当广谱的抗癌活性。然而，这种活性由于其相当大的不稳定性而受到抑制，因为太不稳定而不能用作治疗剂。使用最先进的方法，我们将快速生成更稳定和具有生物活性的抑癌素类似物的文库，并研究它们作为抗癌药物的潜力。这个项目为澳大利亚提供了一个机会，在迄今为止无法预见的治疗药物的开发方面取得了重大的、创新的领先地位。

The natural product, Fostriecin, displays considerable broad-spectrum anti-cancer activity, acting via a novel mechanism. However, this activity is tempered by its considerable instability, being too unstable to be used as a therapeutic agent. Using state-of-the-art approaches we will, rapidly generate libraries of more stable and biologically active fostriecin analogues and examine their potential to be used anti-cancer agents. This project represents an opportunity for Australia to take a significant, innovative lead in the development of hitherto unforseen therapeutic agents.