Pushing The Boundaries Of Flow Chemistry – Towards New Anti-Viral Agents

新药的合成化学方法依赖于获得强大可靠的反应。传统上，这些方法是非常浪费的，制药行业每公斤产品产生5到100公斤的废物。全流动化学方法将显著减少废物，实现快速反应序列优化，并无缝放大。在跨越澳大利亚、德国和美国的合作努力中，作为现实世界应用的典范，该项目不仅将在增强和更环保的合成方法方面产生好处，而且还将在小分子识别策略的开发方面产生好处，小分子是抗病毒药物新作用类别的先驱。

Synthetic chemistry approaches to new drugs rely on access to robust reliable reactions. Traditionally these approaches are highly wasteful with the pharmaceutical industries producing five to a hundred kilograms of waste per kilogram of product. Total flow chemistry approaches will significantly reduce waste, allow rapid reaction sequence optimisation, and seamless scale up. In a collaborative effort spanning Australia, Germany and the USA, in an exemplar of a real world application, this project will produce benefits not only in enhanced and greener synthetic approaches, but also in the development of strategies for the identification of small molecules, the precursors to a new mode of action class of anti-viral drugs.