Pushing The Boundaries Of Flow Chemistry – Towards New Anti-Viral Agents

突破流动化学的界限 — 开发新型抗病毒药物

• 批准号: DP140101565
• 负责人: Prof Adam McCluskey
• 金额: $ 29.17万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-05-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101565
• 关键词: Pushing; Boundaries; Flow; Chemistry; Towards

Synthetic chemistry approaches to new drugs rely on access to robust reliable reactions. Traditionally these approaches are highly wasteful with the pharmaceutical industries producing five to a hundred kilograms of waste per kilogram of product. Total flow chemistry approaches will significantly reduce waste, allow rapid reaction sequence optimisation, and seamless scale up. In a collaborative effort spanning Australia, Germany and the USA, in an exemplar of a real world application, this project will produce benefits not only in enhanced and greener synthetic approaches, but also in the development of strategies for the identification of small molecules, the precursors to a new mode of action class of anti-viral drugs.

新药的合成化学方法依赖于稳健可靠的反应。传统上，这些方法非常浪费，制药行业每公斤产品会产生五到一百公斤废物。全流程化学方法将显着减少浪费，实现快速反应序列优化和无缝放大。在澳大利亚、德国和美国的合作中，作为现实世界应用的典范，该项目不仅将在增强和更绿色的合成方法方面产生效益，而且还将在开发识别小分子的策略方面产生效益，小分子是抗病毒药物新作用模式的前体。