Micro-dissection of clathrins role in mitosis via chemical biology probes

通过化学生物学探针显微解剖网格蛋白在有丝分裂中的作用

• 批准号: DP180101781
• 负责人: Prof Adam McCluskey
• 金额: $ 56.66万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-02-09 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101781
• 关键词: Micro; dissection; clathrins; role; mitosis

This project aims to contribute to understanding the molecular mechanisms of the role of a key protein, clathrin, in cell division. In doing so it expects to reveal new approaches to stop uncontrolled cell division and proliferation, the hallmarks of cancer. The outcomes could in the long term inform breakthroughs in cancer treatment, significant enhancements in life quality and a reduction in cancer death rates.

该项目旨在帮助理解关键蛋白质网格蛋白在细胞分裂中作用的分子机制。通过这样做，它希望揭示新的方法来阻止不受控制的细胞分裂和增殖，这是癌症的标志。从长远来看，这些结果可能会带来癌症治疗的突破、生活质量的显着提高和癌症死亡率的降低。