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Development of a large scale and phyiologically detailed mathematical model of the brainstem and spinal cord neuronal networks

开发脑干和脊髓神经元网络的大规模且生理学详细的数学模型

基本信息

批准号：
16300154
负责人：
NOMURA Taishin
金额：
$ 8.96万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

This study aimed at constructing a large scale and physiologically detailed mathematical model of the brainstem-spinal cord neuronal network. We tried, as much as possible, to reconstruct three dimensional structure and electrophysiological characteristics of the neuronal network based on previous knowledges in the field of neuroanatomy and electrophysiology including the conductances of ion channels of neurons. The modeling was performed using hierarchical and distributed representations of the network elements (from the ion channels, the cells, the sypnapses) to the network. To this end, we used thoroughly object-orinted modeling methodology, by which we developed a software system that could systematize large scale modeling and simulation processes. Using this software system, we constructed a brainstem spinal neuronal network model consisting of 224 biophysically plausible neuron models which were spatially distributed and synoptically connected by excitatory and inhibitory synapses in the brain-stem spinalcord of cat. The spatio-temporal dynamic of the model were then simulated using PC cluster with 64-CPU. It was confirmed that the model showed bursting and oscillatory electrical activity. The bursting activity was alternating between left and right of the network as well as extensor and flexor interneurons within each of the left and right spinal segment, similar to the electrical activity of locomotor or respiratory neural networks.

本研究旨在构建脑干-脊髓神经网络的大尺度、生理细节化的数学模型。我们基于神经解剖学和电生理学领域的现有知识，包括神经元离子通道的电导，尽可能地重建神经元网络的三维结构和电生理特征。建模使用网络元素（从离子通道、细胞、突触）到网络的分层和分布式表示来执行。为此，我们彻底采用了面向对象的建模方法，通过这种方法，我们开发了一个可以将大规模建模和仿真过程系统化的软件系统。利用该软件系统，我们构建了一个由224个生物物理上合理的神经元模型组成的脑干脊髓神经网络模型，这些神经元模型在空间上分布，并通过兴奋突触和抑制性突触进行气候性连接。采用64-CPU的PC集群对模型进行了时空动态仿真。结果表明，该模型具有爆裂性和振荡性的电活动。爆发活动在左右神经网络以及左右脊柱节段内的伸肌和屈肌中间神经元之间交替发生，类似于运动或呼吸神经网络的电活动。