A general research in order to evaluate the metabolic risk of obesity in children and effect of health support program for them.

一项旨在评估儿童肥胖代谢风险及其健康支持计划效果的一般性研究。

• 批准号: 16300195
• 负责人: ADACHI Minoru
• 金额: $ 9.79万
• 依托单位: OKYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300195/
• 关键词: Childhood obesity; Evaluation; Support program; System development; Physical activity; 食事

The prevalence of pediatric obesity and the risk of metabolic syndrome (MS) are increasing in Japanese school children. In adults, obesity such as high levels of central body fatness, especially visceral adipose tissue (VAT), are associated with risk factors for coronary heart disease, hypertension, and non insulin-depended diabetes mellitus. The purpose of the present research was to evaluate the metabolic risk and VAT area in obese children and effect of health support program for them. In this summary, we will focus our attention on the relationship between VAT and MS in obese children.We examined the relationship between VAT area and MS in 392 (boys 212, girls 174) obese children 6 to 14 years old. VAT and subcutaneous adipose tissue (SAT) were measured by computed tomography at the level of the umbilicus. The parameters of MS were used of blood pressure (SBP and DBP) and clinical blood biochemistry. A threshold value of metabolic derangement was calculated, using the analysis of receiver operating characteristic (ROC) curve.VAT area was closely associated TG, HDL-c, SBP, DBP, alanine aminotransferase, and uric acid in boys and girls except the influence of age. Pearson's correlation coefficient values were higher in girls than in boys. VAT gave 70% sensitivity and specificity in boys, and 70% sensitivity and 90% specificity in girls. The threshold values for VAT area were 55cm^2 in both boys and girls.These results suggested that threshold values of VAT area (55cm^2) be able to classify childhood obese type into with medical problem and those without.

在日本学龄儿童中，儿童肥胖的患病率和代谢综合征(MS)的风险正在增加。在成年人中，肥胖，如高水平的中心体脂，特别是内脏脂肪组织(VAT)，与冠心病、高血压和非胰岛素依赖型糖尿病的危险因素有关。本研究的目的是评估肥胖儿童的代谢风险和增值税面积，以及健康支持计划的效果。本文对392例肥胖儿童(男212例，女174例)6~14岁肥胖儿童的增值税面积与多发性硬化的关系进行了研究。在脐部水平通过计算机断层扫描测量VAT和皮下脂肪组织(SAT)。MS参数用于血压(SBP和DBP)和临床血生化。用受试者工作特征(ROC)曲线分析计算代谢紊乱的阈值，除年龄影响外，男性和女孩的VAT面积与TG、HDLc、SBP、DBP、丙氨酸氨基转移酶、尿酸密切相关。皮尔逊相关系数女孩高于男孩。VAT对男孩的敏感性和特异性为70%，对女孩的敏感性和特异性分别为70%和90%。男女儿童VAT面积阈值均为55 cm~2，提示VAT面积阈值(55 cm~2)可将儿童肥胖型分为有病史和无病史两类。