Analysis of the stress resistance functions of Prolyl Isomerase Pin1

这是我们发现的。Pin1是一种抗应激蛋白，与癌症和阿尔茨海默病有关。Pin1调控癌基因c-myc的稳定性。C-myc被泛素化降解。如果myc没有降解并留在细胞内，细胞就会永生并发展为癌细胞。因此，Pin1具有抵抗肿瘤发展应激的功能。没有Pin1和P53的小鼠发生胸腺瘤，这是由于过量产生NIC，激活Notch1引起的。Pin1还抑制Notch1的肿瘤信号。在大脑中，Pin1调节淀粉样前体蛋白产生淀粉样β蛋白。Pin1与磷酸化Thr668结合，改变g-分泌酶切割位点的构象。淀粉样β蛋白的产生被认为是阿尔茨海默病发展过程中最重要的事件之一。我们的发现将有助于诊断和生产治疗阿尔茨海默病的药物。我们还发现Pin1激活了STAT3信号，这与炎症和免疫有关。这是另一个表明这一点的例子。品脱是对细胞或身体的压力的响应者。我们还发现。PIN1抑制脊髓损伤引起的细胞凋亡。我们猜测，体内有像Pin1这样的分子可以被抑制。并发现Gas7具有与Pin T相似的氨基酸序列。阿尔茨海默病患者大脑中的Gas7水平非常低。我们认为Gas7可能是另一个像Pin1一样的应激反应蛋白。

We found that. Pin1 is a stress resistance protein that is related to cancer and Alzheimer's disease. Pin1 regulates the stability of an oncogene, c-myc. C-myc is degraded by ubiquitination. If myc is not degraded and remains in the cell, the cell becomes immortalized and develops to cancer cell. Therefore Pin1 functions to resist to the stress of tumor development. The mice without Pin1 and p53 developed thymoma, which is caused by over production of NIC, activated Notch1. Pin1 also suppresses the tumor signal of Notch1. In brains, Pin1 regulate the production of Amyloid beta from amyloid precursor protein. Pin1 binds to the phosphoThr668 and changes the conformation of the site cut by g-secretase. Production of amyloid beta is considered one of the most important events in the development of Alzheimer's disease. Our finding will be useful to diagnose and produce a drug for Alzheimer's disease. We also discovered that Pin1 activates Stat3 signal, which is related to inflammation and immunity. This is the other example showing that. Pint is a responder to the stress to the cell or body. We also found that. Pin1 suppresses the apoptosis caused by spinal cord injury. We guessed there are molecules that function like Pin1 in the body to suppress. The stress, and found Gas7 that has similar amino acid sequence to Pin T. The level of Gas7 is very low in the brains of the patients with Alzheimer's disease. We think Gas7 may be another stress responsive protein like Pin1.