Development of Extra High Cross-Linkage Structured Resin without Environmental Endocrine Disruptor

无环境内分泌干扰物的超高交联结构树脂的开发

• 批准号: 16390556
• 负责人: TANAKA Jiro
• 金额: $ 9.02万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390556/
• 关键词: Endocrine disrupter; Environmental endocrine disrupter; Estrogenic activity; Cross-linkage; Acidic monomer; Hydrogen bond; Covalent bond; Difunctional monomer; 高分子構造・物性; 生体材料; 架橋密度; 耐水性; 内分泌攪乱作用; ビスフェノール-A; 芳香環; ウレタンジメタクリレート; メタクリル酸; 架橋構造

We have been aimed at the development of a high performance dental matrix resin without the environmental endocrine disruptor. We tried to improve the mechanical properties of resins controlling the cross-linked structure using both of the covalent and hydrogen bonds. As a result, we attained to the synthesis of high performance resin, which is high toughness even with high strength and high rigidity, composed of urethane dimethacrylate (UDMA) and methacrylic acid (MAA). All the mechanical properties of UDMA/MAA resin were superior to those of conventional matrix resins composed of tri(ethylene glycol) dimethacrylate (TEGDMA) as a diluent comonomer in both of Halogen and Xenon light source for photo-polymerization though those of all resins had been changed by the light source. The feature of UDMA/MAA resin was to have had toughness simultaneously with strength and rigidity. Especially, this feature was remarkable in the Xenon light source. Above-mentioned result shows that the mechani … More cal properties of the resin are greatly dependent on the overall structure as well as with the conversion achieved. The heat-treatment after photo-polymerization has been effective to improve the mechanical properties of all resins. The tendency was especially noted in UDMA based resin. After thermo-polymerization, the flexural strength of the UDMA/MAA resin was about 300 MPa while those of the conventional resins composed of TEGDMA were about 200 MPa. The fatigue strength, water durability and wear resistance of UDMA/MAA resin were all more excellent than the conventional resin. Consequently, the UDMA/MAA resin has united all mechanical properties at an extremely high level. In addition, UDMA/MAA resin showed behavior similar to the conventional dental matrix resin on the cell culture. Therefore, UDMA/MAA resin has shown the possibility of replace the conventional dental matrix resins composed of TEGDMA as a diluent comonomer and of appear the high-performance resin based composite materials. Less

我们一直致力于开发一种不含环境内分泌干扰物的高性能牙科基质树脂。我们试图通过控制共价键和氢键的交联结构来提高树脂的力学性能。因此，我们得到了合成高性能树脂，这是高韧性，甚至高强度和高刚度，由聚氨酯二甲基丙烯酸酯（UDMA）和甲基丙烯酸（MAA）。在卤素光源和氙气光源下进行光聚合时，尽管所有树脂的力学性能都因光源而发生变化，但UDMA/MAA树脂的各项力学性能均优于以三乙二醇二甲基丙烯酸酯（TEGDMA）为共聚单体稀释剂的传统基体树脂的力学性能，为上级。UDMA/MAA树脂的特点是具有韧性和强度、刚性并存的特点。特别是，这一特点是显着的氙气光源。上述结果表明， ...更多信息 树脂的热性能在很大程度上取决于整体结构以及所实现的转化率。光聚合后的热处理对提高树脂的力学性能是有效的。这种趋势在UDMA基树脂中尤为明显。热聚合后，UDMA/MAA树脂的弯曲强度为约300 MPa，而由TEGDMA组成的常规树脂的弯曲强度为约200 MPa。UDMA/MAA树脂的疲劳强度、耐水性和耐磨性均优于常规树脂。因此，UDMA/MAA树脂以极高的水平统一了所有机械性能。此外，UDMA/MAA树脂在细胞培养上表现出与常规牙科基质树脂相似的行为。因此，UDMA/MAA树脂有可能取代以TEGDMA为稀释剂的传统牙科基质树脂，成为高性能的树脂基复合材料。少

项目成果

Surface Treatment with N, N'-Dimethacryloylcystine for Enhanced Bonding of Resin on Dental Alloys

N,N-二甲基丙烯酰胱氨酸表面处理增强树脂与牙科合金的结合力

• 发表时间: 2007
• 期刊: Dental Materials Journal 26(in press)
• 作者: Jiro Tanaka;Jeffery W.Stansbury;Joseph M.Antonucci;Kazuomi Suzuki
• 通讯作者: Kazuomi Suzuki

Surface Treatment with N, N'-Dimethacryloylcystine for Enhanced Bonding of Resin to Dental Alloys

用 N,N-二甲基丙烯酰胱氨酸进行表面处理以增强树脂与牙科合金的粘合

• 发表时间: 2006
• 期刊: Dental Materials Journal (in press)
• 作者: Jiro Tanaka;Jeffery W.Stansbury;Joseph M.Antonucci;Kazuomi Suzuki;Marianera Trujillo-Lemon;Marianela Trujillo・Lemon;Jiro Tanaka
• 通讯作者: Jiro Tanaka

Development of High Strength - High Modulus-High Toughness Dental Marix Resin Ability of Urethane Dimethacrylate/Methacrylic Acid Resin -

聚氨酯二甲基丙烯酸酯/甲基丙烯酸树脂的高强度、高模量、高韧性牙科基质树脂能力的开发 -

• 发表时间: 2005
• 期刊: Journal of the Japanese Association for Dental Science 24
• 作者: Marianel Trujillo-Lemon;Junhao Ge;Hui Lu;Jiro Tanaka;Jefery W.Stansbury;Marianela Trujillo-Lemon;Yamamoto T;田仲持郎;Lewis JB;Jiro Tanaka
• 通讯作者: Jiro Tanaka

内分泌撹乱物質を含まない高強度・高弾性・高靭性歯科用レジンの開発

开发不含内分泌干扰物的高强度、高弹性、高韧性牙科树脂

• 发表时间: 2004
• 期刊: 日本歯科医学会誌 23
• 作者: Tsuchimoto.Y.;Yoshida;Y.et al.;Hsu S;田仲持郎
• 通讯作者: 田仲持郎

医療用樹脂組成物, 樹脂組成物の製造方法及び成形品の製造方法

医用树脂组合物、树脂组合物的制造方法以及成形体的制造方法

• 发表时间: 2006