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Present status and origin of drug resistant malaria parasites in Indonesia

印度尼西亚耐药疟原虫的现状和起源

基本信息

批准号：
16406011
负责人：
KANBARA Hiroji
金额：
$ 6.72万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

Indonesia is a big archipelago country consisting of various races and environments, resulting in diverse malaria endemic situations according to different islands, and often even in a single island. So far, this diversity had been dependent upon the above factors, but it has been rapidly changed by the socio-economical change. Urbanization dramatically reduced malaria endemics, especially in Java and Bali island. In our survey areas, in Lombok and Sumbawa island, the major malaria endemics along the coasts have decreased due to economical development except some remote, rural areas, but the economical development and resultant increase in population expanded the human life range to surrounding mountains (or forested hills). Now, in our survey areas in Lombok, most of malaria cases are found in forested hills. The same situation was found in new transmigrant villages in the south of Sumbawa district. Factors involving malaria epidemic in new settlements are under investigation. A common factor seen in all the malaria endemic areas is their location far separated from medical facilities. Interesting points are that most of villagers over 10 years old in endemic areas have acquired anti-malaria immunity regardless of less degree of endemicity compared with high degree of endemicity in Africa where most of residents gradually acquire anti-malaria immunity with increasing age. In a new settlement with 7 or 8 years history, villagers over 15 years old also showed apparent malaria immunity, indicating age-dependent malaria immunity. In all the survey areas prevalent chloroquine resistance of Plasmodium falciparum was demonstrated by analyzation of related genes.

印度尼西亚是一个由不同种族和环境组成的群岛大国，导致不同岛屿、甚至单个岛屿的疟疾流行情况不同。迄今为止，这种多样性一直取决于上述因素，但随着社会经济的变化，这种多样性已经迅速改变。城市化极大地减少了疟疾流行，特别是在爪哇岛和巴厘岛。在我们的调查地区，龙目岛和松巴哇岛，除一些边远农村地区外，沿海主要疟疾流行由于经济发展而有所减少，但经济发展和人口的增加将人类的生活范围扩大到周围的山区（或森林山丘）。现在，在我们龙目岛的调查区域，大多数疟疾病例都发现在森林覆盖的山丘中。在松巴哇县南部的新移民村庄也发现了同样的情况。新定居点的疟疾流行因素正在调查中。所有疟疾流行地区的一个共同因素是其位置远离医疗设施。有趣的是，尽管流行程度较轻，但流行地区10岁以上的村民大多数都获得了抗疟疾免疫力，而非洲流行程度较高，大多数居民随着年龄的增长逐渐获得抗疟疾免疫力。在一个有7、8年历史的新聚落中，15岁以上的村民也表现出明显的疟疾免疫力，表明疟疾免疫力具有年龄依赖性。通过对相关基因的分析，证明了所有调查地区普遍存在恶性疟原虫对氯喹的耐药性。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Review : Malaria endemic patterns on Lombok and Sumbawaislands,Indonesia.

回顾：印度尼西亚龙目岛和松巴威群岛的疟疾流行模式。

DOI：
发表时间：
2005
期刊：
Tropical Medicine and Health 33(2)
影响因子：
0
作者：
Saka;H.;Morita;S.;Yamagishi;J.;Abe;J.;Kamoshita;A.;Yoes P.Dachlan et al.
通讯作者：
Yoes P.Dachlan et al.

Short report:: Polymorphisms in the chloroquine resistance transporter gene in Plasmodium falciparum isolates from Lombok, Indonesia

DOI：
10.4269/ajtmh.2004.71.40
发表时间：
2004-07-01
期刊：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
影响因子：
3.3
作者：
Huaman, MC;Yoshinaga, K;Kanbara, H
通讯作者：
Kanbara, H

Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax

DOI：
10.1093/molbev/msi168
发表时间：
2005-08-01
期刊：
MOLECULAR BIOLOGY AND EVOLUTION
影响因子：
10.7
作者：
Jongwutiwes, S;Putaporntip, C;Hughes, AL
通讯作者：
Hughes, AL

Review : Malaria endemic patterns on Lombok and Sumbawa islands, Indonesia.

回顾：印度尼西亚龙目岛和松巴哇岛的疟疾流行模式。

DOI：
发表时间：
2005
期刊：
Tropical Medicine and Health, 33(2)
影响因子：
0
作者：
Saka;H.;Morita;S.;Yamagishi;J.;Abe;J.;Kamoshita;A.;Yoes P.Dachlan et al.;Chaturong Putaporntip et al.;Yoes P.Dachlan et al.
通讯作者：
Yoes P.Dachlan et al.

Short communication : Ancient common ancestry of the merozoite surface protein 1 of Plasmodium vivax as inferred from its homologue in Plasmodium knowlesi.

简短交流：从诺氏疟原虫中的同源物推断出间日疟原虫裂殖子表面蛋白 1 的古代共同祖先。