Examination of inhibitory effects of anti-oxidants on progression of HIV-1 infection -A cohort study in Thailand -

检查抗氧化剂对 HIV-1 感染进展的抑制作用 - 泰国队列研究 -

• 批准号: 16406017
• 负责人: HOSHINO Hiroo
• 金额: $ 6.08万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16406017/
• 关键词: HIV; Antioxidants; Green tea extract; Thailand; Cohort study; HIV-1; 緑茶抽出物; Viral load; チェンマイ大学

A specific feature of HIV-1 infection in Asian countries has been examined in collaboration with Faculty of Medicine, Chiang Mai University. In Thailand there are already some 600 thousand subjects infected with HIV-1 and 20 thousand of them are infants or children. In some children infected with HIV-1, the disease will progress more rapidly than infected adults. Therefore, effects or side-effects of antiviral treatment can be judged earlier through their follow-up. In the suburb of Chiang Mai City, there is a national facility to take care of HIV-1-infected children. These children have been medically observed and treated in a national hospital or Chiang Mai University Hospital. Thus, we have made a good control with a cohort to readily compare the clinical status of HIV-1-infected children with their virological markers or their treatment.There is much evidence showing that antioxidants will inhibit the development of various caners. In contrast, oxidative stress or TNF a will activa … More te chronical viral infection including HIV-1, and thus promote the progression of diseases associated with chronical virus infection. Green tea extract or asthaxanthin, having anti-oxidant activities and inhibiting TNFα production, may retard the progression of HIV-1- related diseases. We have prepared to perform an intervening study for this.We have identified new coreceptors for HIV-1 infection. Using peripheral blood lymphocytes of Japanese subjects or Thai children infected with HIV-1, clinical and epidemiological significance of new coreceptors has been studied. One coreceptor was used by dual-tropic subtype-B HIV-1, while another one by subtype AE or C HIV-1 of Thai or Vietnamese origins.During the study period of this research, a Thai rule for export of clinical samples has become very strict. It takes time to obtain the permission to bring Thai samples abroad. For intervening epidemiological studies, it is necessary to obtain a permission from the ethical committee of Chiang Mai University. It will also take time for this. We are preparing to obtain these types of permission. Although our study has been retarded by these changes. Less

与清迈大学医学院合作，对亚洲国家HIV-1感染的一个具体特点进行了研究。在泰国，已经有大约60万人感染了HIV-1，其中2万人是婴儿或儿童。在一些感染HIV-1的儿童中，疾病的进展速度会比感染的成年人更快。因此，抗病毒治疗的效果或副作用可以通过随访更早地判断。在清迈市的郊区，有一个国家设施照顾感染艾滋病毒1的儿童。这些儿童在国立医院或清迈大学医院接受了医学观察和治疗。因此，我们已经做了一个很好的控制与队列容易比较HIV-1感染儿童的临床状态与他们的病毒学标志物或他们的治疗。有很多证据表明，抗氧化剂将抑制各种癌症的发展。相反，氧化应激或TNF a会激活细胞， ...更多信息 因此，本发明的组合物可抑制包括HIV-1在内的慢性病毒感染，并因此促进与慢性病毒感染相关的疾病的进展。绿色茶提取物或黄曲霉素具有抗氧化活性并抑制TNFα的产生，可延缓HIV-1相关疾病的进展。我们已经准备对此进行干预研究，我们已经确定了HIV-1感染的新的辅助受体。使用日本受试者或泰国儿童感染HIV-1的外周血淋巴细胞，研究了新的辅助受体的临床和流行病学意义。一个辅助受体用于双嗜性B亚型HIV-1，而另一个用于泰国或越南来源的AE或C亚型HIV-1。获得许可将泰国样品带到国外需要时间。对于干预性流行病学研究，必须获得清迈大学伦理委员会的许可。这也需要时间。我们正在准备获得这类许可。尽管我们的研究受到了这些变化的阻碍。少

项目成果

Human T-cell leukaemia virus type I is highly sensitive to UV-C light.

人类 T 细胞白血病病毒 I 型对 UV-C 光高度敏感。

• 发表时间: 2004
• 期刊: J Gen Virol. 85
• 作者: Shimizu A;Shimizu N;Tanaka A;Jinno-Oue A;Roy BB;Shinagawa M;Ishikawa O;Hoshino H.
• 通讯作者: Hoshino H.

The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 human immunodeficiency virus type 1

源自孤儿 G 蛋白偶联受体 GPR1 NH2 末端胞外区的合成肽优先抑制 X4 人类免疫缺陷病毒 1 型的感染

• 发表时间: 2005
• 期刊: Journal of Biological Chemistry 280
• 作者: Jinno-Oue;A.;N.Shimizu;Y.Soda;A.Tanaka;T.Otsuki;D.Kurosaki;Y.Suzuki;H.Hoshino
• 通讯作者: H.Hoshino

Isolation of the feline alpha1,3-galactosyltransferase gene, expression in transfected human cells and its phylogenetic analysis.

猫α1,3-半乳糖基转移酶基因的分离、在转染的人类细胞中的表达及其系统发育分析。

• 发表时间: 2006
• 期刊: J Exp Zoolog B Mol Dev Evol 306
• 作者: Roy BB;Jinno-Oue A;Shinagawa M;Shimizu A;Tamura K;Shimizu N;Tanaka A;Hishino H.
• 通讯作者: Hishino H.