Examination of inhibitory effects of anti-oxidants on progression of HIV-1 infection -A cohort study in Thailand -

与清迈大学医学院合作，研究了亚洲国家艾滋病毒-1感染的一个具体特征。在泰国，已经有大约60万人感染了艾滋病毒-1，其中2万人是婴儿或儿童。在一些感染HIV-1的儿童中，疾病的发展速度会比感染的成年人更快。因此，通过随访可以更早地判断抗病毒治疗的效果或副作用。在清迈市郊区，有一个国家设施来照顾感染HIV-1的儿童。这些儿童在国立医院或清迈大学医院接受了医学观察和治疗。因此，我们已经做了一个很好的对照，可以很容易地将HIV-1感染儿童的临床状况与他们的病毒学标志或他们的治疗进行比较。有很多证据表明，抗氧化剂可以抑制各种癌症的发展。相反，氧化应激或肿瘤坏死因子a会激活…。更多的慢性病毒感染，包括艾滋病毒-1，从而促进与慢性病毒感染有关的疾病的进展。绿茶提取物或软黄素具有抗氧化活性，抑制肿瘤坏死因子α的产生，可能延缓HIV-1相关疾病的进展。我们已经准备对此进行一项干预研究。我们已经确定了HIV-1感染的新的辅助受体。利用感染HIV-1的日本受试者或泰国儿童的外周血淋巴细胞，研究了新的辅受体的临床和流行病学意义。一个辅助受体由双嗜性B亚型HIV-1使用，另一个由泰国或越南来源的AE或C亚型HIV-1使用。在本研究的研究期间，泰国对临床样本出口的规定变得非常严格。将泰国样本带到国外需要时间才能获得许可。对于干预流行病学研究，必须获得清迈大学伦理委员会的许可。这也需要时间。我们正在准备获得这些类型的许可。尽管这些变化阻碍了我们的研究。较少

A specific feature of HIV-1 infection in Asian countries has been examined in collaboration with Faculty of Medicine, Chiang Mai University. In Thailand there are already some 600 thousand subjects infected with HIV-1 and 20 thousand of them are infants or children. In some children infected with HIV-1, the disease will progress more rapidly than infected adults. Therefore, effects or side-effects of antiviral treatment can be judged earlier through their follow-up. In the suburb of Chiang Mai City, there is a national facility to take care of HIV-1-infected children. These children have been medically observed and treated in a national hospital or Chiang Mai University Hospital. Thus, we have made a good control with a cohort to readily compare the clinical status of HIV-1-infected children with their virological markers or their treatment.There is much evidence showing that antioxidants will inhibit the development of various caners. In contrast, oxidative stress or TNF a will activa … More te chronical viral infection including HIV-1, and thus promote the progression of diseases associated with chronical virus infection. Green tea extract or asthaxanthin, having anti-oxidant activities and inhibiting TNFα production, may retard the progression of HIV-1- related diseases. We have prepared to perform an intervening study for this.We have identified new coreceptors for HIV-1 infection. Using peripheral blood lymphocytes of Japanese subjects or Thai children infected with HIV-1, clinical and epidemiological significance of new coreceptors has been studied. One coreceptor was used by dual-tropic subtype-B HIV-1, while another one by subtype AE or C HIV-1 of Thai or Vietnamese origins.During the study period of this research, a Thai rule for export of clinical samples has become very strict. It takes time to obtain the permission to bring Thai samples abroad. For intervening epidemiological studies, it is necessary to obtain a permission from the ethical committee of Chiang Mai University. It will also take time for this. We are preparing to obtain these types of permission. Although our study has been retarded by these changes. Less