Examination of inhibitory effects of anti-oxidants on progression of HIV-1 infection -A cohort study in Thailand -

与清迈大学医学院合作，研究了亚洲国家HIV-1感染的一个具体特征。在泰国，已经有大约60万人感染了艾滋病毒-1，其中2万人是婴儿或儿童。在一些感染HIV-1的儿童中，这种疾病的发展速度比受感染的成年人要快。因此，通过随访可以更早地判断抗病毒治疗的效果或副作用。在清迈市郊区，有一个照顾感染艾滋病毒1的儿童的国家设施。这些儿童在国立医院或清迈大学医院接受了医学观察和治疗。因此，我们通过一个队列进行了很好的对照，可以很容易地将hiv -1感染儿童的临床状况与其病毒学标志物或治疗进行比较。有很多证据表明抗氧化剂可以抑制各种癌症的发展。相反，氧化应激或TNF a会激活包括HIV-1在内的慢性病毒感染，从而促进慢性病毒感染相关疾病的进展。绿茶提取物或烟黄素具有抗氧化活性和抑制TNFα的产生，可能延缓HIV-1相关疾病的进展。我们准备对此进行干预研究。我们已经确定了HIV-1感染的新辅受体。利用日本人和泰国HIV-1感染儿童的外周血淋巴细胞，研究了新的辅助受体的临床和流行病学意义。一种辅助受体用于双向b亚型HIV-1，另一种用于泰国或越南起源的AE或C亚型HIV-1。在本研究的研究期间，泰国对临床样品出口的规定变得非常严格。获得将泰国样品带到国外的许可需要时间。对于介入流行病学研究，必须获得清迈大学伦理委员会的许可。这也需要时间。我们正准备获得这些类型的许可。尽管这些变化阻碍了我们的研究。少

A specific feature of HIV-1 infection in Asian countries has been examined in collaboration with Faculty of Medicine, Chiang Mai University. In Thailand there are already some 600 thousand subjects infected with HIV-1 and 20 thousand of them are infants or children. In some children infected with HIV-1, the disease will progress more rapidly than infected adults. Therefore, effects or side-effects of antiviral treatment can be judged earlier through their follow-up. In the suburb of Chiang Mai City, there is a national facility to take care of HIV-1-infected children. These children have been medically observed and treated in a national hospital or Chiang Mai University Hospital. Thus, we have made a good control with a cohort to readily compare the clinical status of HIV-1-infected children with their virological markers or their treatment.There is much evidence showing that antioxidants will inhibit the development of various caners. In contrast, oxidative stress or TNF a will activa … More te chronical viral infection including HIV-1, and thus promote the progression of diseases associated with chronical virus infection. Green tea extract or asthaxanthin, having anti-oxidant activities and inhibiting TNFα production, may retard the progression of HIV-1- related diseases. We have prepared to perform an intervening study for this.We have identified new coreceptors for HIV-1 infection. Using peripheral blood lymphocytes of Japanese subjects or Thai children infected with HIV-1, clinical and epidemiological significance of new coreceptors has been studied. One coreceptor was used by dual-tropic subtype-B HIV-1, while another one by subtype AE or C HIV-1 of Thai or Vietnamese origins.During the study period of this research, a Thai rule for export of clinical samples has become very strict. It takes time to obtain the permission to bring Thai samples abroad. For intervening epidemiological studies, it is necessary to obtain a permission from the ethical committee of Chiang Mai University. It will also take time for this. We are preparing to obtain these types of permission. Although our study has been retarded by these changes. Less