A specification of a population leading to an HIV epidemic in the Philippines, and modeling of the entry sites and the resultant circulation routes of foreign HIV strains into and in the country.

对导致菲律宾艾滋病毒流行的人口进行了详细说明，并对外国艾滋病毒毒株进入该国和在该国境内的入境地点和由此产生的传播路线进行了建模。

基本信息

批准号：
16406014
负责人：
KAGEYAMA Seiji
金额：
$ 7.49万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2007
项目状态：
已结题

项目摘要

The monitoring of an HIV infection is important for the prevention of an outbreak. However, it is difficult to identify the early phase of an epidemic only by HIV monitoring and we add the monitoring of Hepatitis C virus (HCV) to be used for a surrogate marker of blood-borne IIN infection. Blood-borne HIV infections have been considered to be the spread measures at initial phase of an outbreak before sexual contact-related infections.Surveillance areas have been organized in Luzon, Visaya, and Mindanao in the Philippines, and totally 2,645 samples have been tested including 1,494 ones from injecting drug users (IDUs). HIV has been rarely detected, which supports the low prevalence of HIV infection in the Philippines. However, the blood-borne HCV infections are prevalent among IDUs and dialysis patients. The percentage of HCV infections among IDUs at downtown in Metro Cebu (the center of Visaya) were 8936 although that of HIV was few, 0.40%. The profiles of HCV indicated that the variety of the strains prevalent in Metro Manila (capital of the Philippines and the center of Luzon) has been biggest Subtype-1b, genotype-4 and 6 were only observed in Metro Manila Moreover, some of them strains bad higher homology to foreign strains than those prevalent in Metro Manila. The strains variety may indicate that the foreign strains may preferentially enter into Metro Manila than other areas. Some strains collected in three areas (shown above) mixed together in the Phylogenetic trees, suggesting HCV stains may circulate quickly in the Philippines.The results of HCV study indicate that WV may enter into Metro Manila and circulate into other area in the Philippines.

对艾滋病毒感染的监测对于预防疫情很重要。但是，只有通过HIV监测，很难识别流行病的早期阶段，我们添加对丙型肝炎病毒（HCV）的监测，以用于血液传播IIN感染的替代标记。在与性接触相关感染之前，爆发的初始阶段，血源性的HIV感染已被认为是菲律宾吕宋岛，米沙ya和棉兰老岛的估算区域的传播措施，总共测试了2,645个样品，包括1,494个样品，包括1,494个注射药物使用者（IDUS）。很少检测到艾滋病毒，这支持菲律宾艾滋病毒感染的较低患病率。但是，血源性HCV感染在IDU和透析患者中普遍存在。宿雾市中心（米沙ya）市中心IDU的HCV感染百分比为8936，尽管艾滋病毒很少，0.40％。 HCV的曲线表明，马尼拉大都会（菲律宾的首都和吕宋岛中心）中普遍存在的菌株是最大的亚型1B，基因型-4和6，仅在马尼拉都会大都会中观察到，其中一些人比Manila中有一些高于MANILA的高级同源物。菌株的品种可能表明，与其他地区相比，外国菌株可能优先进入马尼拉大都会。在系统发育树木中混合的三个区域（如上所示）收集的一些菌株，表明HCV污渍可能在菲律宾迅速循环。HCV研究的结果表明，WV可能进入马尼拉大都会并循环到菲律宾的其他地区。