Virological and clinical study on HIV-2 infection.

在印度发现了血清阴性的HIV-2携带者。从11例HIV-2血清阴性者中检出前病毒HIV-2。HIV-1和HIV-2。从其中两个人的外周血单个核细胞培养中检测到两株HIV-2。分离株为A亚型，成功感染永生化T细胞后，用抗HIV-2抗体检测细胞中的HIV-2抗原。然而，从其分离出HIV-2的个体中的抗体不能与HIV-2抗原结合。这些结果表明印度存在HIV-2病毒。对HIV-2病毒的免疫反应可能有效。这可能归因于HIV-2没有HIV-1增殖那么多的事实。因此，免疫逃避不会经常发生。因此，在某些情况下，抗原量不足以产生血清转换。在三年的观察中，HIV-2 V3环的氨基酸序列没有改变，证实了这一点。进一步的仔细观察仍在进行中，以澄清HIV-2感染的窗口期。免疫逃逸案件也是今后研究的重点。

Seronegative HIV-2 carriers have been found in India. Proviral HIV-2 was detected from 11 seronegative individuals for. HIV-1 and 2. Two HIV-2 strains were detected from the culture of peripheral blood mononuclear cells of two individuals among those. Those isolates belonged to subtype A. After the successful infection to immortalized T cells HIV-2 antigen in the cells was detected by anti-HIV-2 antibody. However, the antibody in the individual from whom HIV-2 was isolated could not be bound to the HIV-2 antigen. Those results imply the presence of HIV-2 in India.The immune response to HIV-2 may act effectively. This may attributed to the fact that HIV-2 does not proliferate as much as HIV-1. Therefore immune evasion does not occur so often. As a result the amount of antigen was not enough to generate seroconversion in some cases. This was corroborated by the no alteration of amino acid sequence in V3-loop of HIV-2 during three years observation. Further careful observation is still on going to clarify the window period of HIV-2 infection as. The case of immune evasion is also focusing on as the future study.