Virological and clinical study on HIV-2 infection.

HIV-2感染的病毒学和临床研究。

• 批准号: 10044253
• 负责人: KAGEYAMA Seiji
• 金额: $ 1.54万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044253/
• 关键词: HIV-2; HIV-1; AIDS; Seronegative; replication; V3-loop

Seronegative HIV-2 carriers have been found in India. Proviral HIV-2 was detected from 11 seronegative individuals for. HIV-1 and 2. Two HIV-2 strains were detected from the culture of peripheral blood mononuclear cells of two individuals among those. Those isolates belonged to subtype A. After the successful infection to immortalized T cells HIV-2 antigen in the cells was detected by anti-HIV-2 antibody. However, the antibody in the individual from whom HIV-2 was isolated could not be bound to the HIV-2 antigen. Those results imply the presence of HIV-2 in India.The immune response to HIV-2 may act effectively. This may attributed to the fact that HIV-2 does not proliferate as much as HIV-1. Therefore immune evasion does not occur so often. As a result the amount of antigen was not enough to generate seroconversion in some cases. This was corroborated by the no alteration of amino acid sequence in V3-loop of HIV-2 during three years observation. Further careful observation is still on going to clarify the window period of HIV-2 infection as. The case of immune evasion is also focusing on as the future study.

在印度发现了血清阴性的HIV-2携带者。从11例血清阴性个体中检测到HIV-2前病毒。HIV-1和2。从其中两个人的外周血单个核细胞培养中检测到2株HIV-2。成功感染永生化T细胞后，用抗HIV-2抗体检测细胞内HIV-2抗原。然而，在分离HIV-2的个体中，抗体不能与HIV-2抗原结合。这些结果表明印度存在HIV-2病毒。对HIV-2的免疫反应可能有效。这可能归因于HIV-2不像HIV-1那样增殖。因此，免疫逃避不会经常发生。结果，在某些情况下，抗原的数量不足以产生血清转化。在3年的观察中，HIV-2病毒v3环的氨基酸序列没有发生改变，证实了这一点。进一步的仔细观察仍在继续，以澄清HIV-2感染的窗口期。免疫逃避的案例也是未来研究的重点。

项目成果

Kageyama, S., Maniar, J. K., Iwasaki, M., Zhang, J., Saple, D. G., Tsuchie, H., Tanabe-Tochikura, A., Taniguchi, K., Shiraki, K., and Kurimura T.: "Seronegative HIV-2 carriers in India."Int J STD AIDS. 11(1). 31-37 (2000)

Kageyama, S.、Maniar, J.K.、Iwasaki, M.、Zhang, J.、Saple, D.G.、Tsuchie, H.、Tanabe-Tochikura, A.、Taniguchi, K.、Shiraki, K. 和 Kurimura T.：

Kageyama, S., et al.: "Seronegative HIV-2 carriers in India"Int. J. STD AIDS. 11. 31-37 (2000)

Kageyama, S. 等人：“印度血清阴性 HIV-2 携带者”Int.

Kageyama, S., et al.: "Seronegative HIV-2 Carriers in India"Int J STD AIDS. 11(1). 31-37 (2000)

Kageyama, S. 等人：“印度的血清阴性 HIV-2 携带者”Int J STD AIDS。

S Kageyama,et al: "Seronegative HIV-2 Carriens in India" Internaticnal J of STD and AIDS. revised. (1999)

S Kageyama 等人：“印度血清阴性 HIV-2 携带者”《国际 STD 和艾滋病杂志》。