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Study for the risk factors of the development of bronchial asthma in Bangladeshi children

孟加拉国儿童支气管哮喘发生危险因素的研究

基本信息

批准号：
16406028
负责人：
IWATA Tsutomu
金额：
$ 3.84万
依托单位：
Tokyo Kasei University (2005)The University of Tokyo (2004)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

So-called hygiene hypothesis is widely discussed in terms of the increasing prevalence of allergic diseases. We already studied and found that the prevalence of bronchial asthma in rural Bangladeshi children aged 5 years old was as high as 16.2% using the International Study of Asthma and Allergies of Childhood (ISAAC) questionnaire. The risk factors in the area were atopic diathesis, the history of pneumonia, and anti-ascaris IgE antibody. The question of this study was the reliability of the diagnosis, because we used questionnaire method.Method : We chose the same field (Matlab tana, Bangladesh) and the study population was same as the former study operated in 2001. All 219 children who showed wheezing history during 12 months prior to the study in 2001 (wheezy group in 2001), 62 children who showed any wheezing history until 12 months before the study in 2001 (past wheezy group in 2001), and 82 from 122 children who did not show any wheezing history (non-wheezy group in 2001) were … More asked for the consent and participation to the study. All participants, whose bronchial hyperresponsiveness (BHR) was tested using inhalation of hypertonic saline, were drawn blood for total IgE, eosinophil count, and specific IgE antibodies against house dust mite and ascaris. Their stools were examined for ova of ascaris and other intestinal parasites. BHR positivity was defined as 15 % or more decrease of FEV1.0.Results and discussion : Total of 317 children aged 9 years old were accomplished the study protocol. Among 194 wheezy group in 2001, 114 were current wheezer (wheezy group in 2005). Seventy one children were categorized as past wheezy group in 2005 and only 9 children were non-wheezy group in 2005. In those three groups, positive BHR was detected in 51 children (55%), 21 (39%), 2 (22%), respectively. The value of anti-ascaris IgE antibody was significantly higher in BHR positive individuals than in BHR negative ones. Further analysis will be necessary for evaluating the risk factors of bronchial asthma in rural Bangladesh. Less

随着变态反应性疾病的日益流行，所谓的卫生假说被广泛讨论。我们已经研究发现，使用儿童哮喘和过敏症国际研究(ISAC)问卷，孟加拉农村5岁儿童哮喘的患病率高达16.2%。危险因素有特应性素质、肺炎病史和抗蛔虫IgE抗体。这项研究的问题是诊断的可靠性，因为我们使用了问卷调查的方法。方法：我们选择相同的领域(孟加拉的MatLab Tana)，研究人群与2001年进行的前一项研究相同。2001年研究前12个月内有喘息史的219名儿童(2001年的喘息组)，2001年研究前12个月内有喘息史的62名儿童(2001年的喘息组)，以及122名没有喘息史的儿童中的82名(2001年的非喘息组)都是…。更多的人要求同意和参与这项研究。所有受试者均吸入高渗盐水进行支气管高反应性(BHR)检测，抽血检测总IgE、嗜酸性粒细胞计数、抗屋尘螨和蛔虫特异性IgE抗体。检查他们的粪便中是否有蛔虫和其他肠道寄生虫的卵子。BHR阳性定义为FEV1.0下降15%或以上。结果与讨论：共有317名9岁儿童完成了研究方案。2001年194例喘息组中，114例为现症喘息组(2005年为喘息组)。2005年有71名儿童被归类为既往喘息组，而2005年只有9名儿童被归类为非喘息组。在这三组中，BHR阳性者分别为51例(55%)、21例(39%)、2例(22%)。BHR阳性者抗蛔虫IgE抗体水平显著高于BHR阴性者。有必要进行进一步的分析，以评估孟加拉国农村地区哮喘的危险因素。较少