Study for the risk factors of the development of bronchial asthma in Bangladeshi children

在变态反应性疾病日益流行的背景下，所谓的卫生假说被广泛讨论。我们已经研究并发现孟加拉国农村5岁儿童支气管哮喘患病率高达16.2%，使用国际儿童哮喘和过敏研究（ISAAC）问卷。该地区的危险因素为特应性素质、肺炎史和抗蛔虫IgE抗体。本研究的问题是诊断的可靠性，因为我们使用问卷调查法。方法：选择与2001年相同的研究区域（Matlab tana, Bangladesh），研究人群与2001年的研究相同。所有219名在2001年研究前12个月有喘息病史的儿童（2001年的喘息组），62名在2001年研究前12个月有任何喘息病史的儿童（2001年的过去喘息组），以及122名没有任何喘息病史的儿童（2001年的非喘息组）中的82名被要求同意并参与研究。吸入高渗生理盐水检测支气管高反应性（BHR）的所有参与者，抽血检测总IgE、嗜酸性粒细胞计数以及针对屋尘螨和蛔虫的特异性IgE抗体。他们的粪便被检查蛔虫和其他肠道寄生虫的卵。BHR阳性定义为FEV1.0下降15%或以上。结果与讨论：共有317名9岁儿童完成了研究方案。在2001年的194个喘息组中，有114个是目前的喘息组（2005年的喘息组）。2005年有71名儿童被归类为过去喘息组，只有9名儿童被归类为非喘息组。在这三组中，分别有51例（55%）、21例（39%）、2例（22%）检测到BHR阳性。BHR阳性个体抗蛔虫IgE抗体值显著高于BHR阴性个体。评估孟加拉国农村地区支气管哮喘的危险因素需要进一步的分析。少

So-called hygiene hypothesis is widely discussed in terms of the increasing prevalence of allergic diseases. We already studied and found that the prevalence of bronchial asthma in rural Bangladeshi children aged 5 years old was as high as 16.2% using the International Study of Asthma and Allergies of Childhood (ISAAC) questionnaire. The risk factors in the area were atopic diathesis, the history of pneumonia, and anti-ascaris IgE antibody. The question of this study was the reliability of the diagnosis, because we used questionnaire method.Method : We chose the same field (Matlab tana, Bangladesh) and the study population was same as the former study operated in 2001. All 219 children who showed wheezing history during 12 months prior to the study in 2001 (wheezy group in 2001), 62 children who showed any wheezing history until 12 months before the study in 2001 (past wheezy group in 2001), and 82 from 122 children who did not show any wheezing history (non-wheezy group in 2001) were … More asked for the consent and participation to the study. All participants, whose bronchial hyperresponsiveness (BHR) was tested using inhalation of hypertonic saline, were drawn blood for total IgE, eosinophil count, and specific IgE antibodies against house dust mite and ascaris. Their stools were examined for ova of ascaris and other intestinal parasites. BHR positivity was defined as 15 % or more decrease of FEV1.0.Results and discussion : Total of 317 children aged 9 years old were accomplished the study protocol. Among 194 wheezy group in 2001, 114 were current wheezer (wheezy group in 2005). Seventy one children were categorized as past wheezy group in 2005 and only 9 children were non-wheezy group in 2005. In those three groups, positive BHR was detected in 51 children (55%), 21 (39%), 2 (22%), respectively. The value of anti-ascaris IgE antibody was significantly higher in BHR positive individuals than in BHR negative ones. Further analysis will be necessary for evaluating the risk factors of bronchial asthma in rural Bangladesh. Less