Cerebellar Interactions with the Amygdala and Prefrontal Cortex during Learning

学习过程中小脑与杏仁核和前额皮质的相互作用

• 批准号: 10550256
• 负责人: John H Freeman
• 金额: $ 37.45万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10550256
• 关键词: Affect; Alzheimer' s Disease; Amygdaloid structure; Anatomy; Animals; Area; Association Learning; Attention; Behavioral; Blinking; Cerebellum; Cognition; Cognitive; Communication; Conditioned Stimulus; Data; Electrophysiology (science); Elements; Emotional; Emotions; Environment; Etiology; Event; Extinction; Feedback; Funding; Goals; Image; Learning; Life; Medial; Mediating; Memory; Memory impairment; Methods; Motor; Nature; Organism; Output; Pathway interactions; Performance; Physiological; Play; Pontine structure; Prefrontal Cortex; Process; Prosencephalon; Rattus; Research; Role; Safety; Short-Term Memory; Signal Transduction; Site; Stimulus; Stroke; Structure; System; Testing; Training; conditioned fear; granule cell; indexing; learned behavior; machine learning algorithm; motor control; motor learning; nervous system disorder; neural; neural circuit; neuromechanism; novel; optogenetics; programs; response; two-photon

Learning is how organisms adapt to changes in their environment and involves the coordination of neural systems mediating cognition, emotion, and motor control. The major goal of the proposed research program is to elucidate the neural circuit mechanisms underlying interactions between cognitive, emotional, and motor systems during associative learning. Interactions between these neural systems are particularly important because the context and emotional significance of stimuli provide essential information for acquisition and performance of motor responses. The breakdown of interactions between cognitive, emotional, and motor systems in various neurological disorders can therefore have devastating consequences for learned behaviors. The prefrontal cortex, amygdala, and cerebellum play significant roles in cognition, emotional responses, and motor learning, respectively. The proposed research program constitutes a comprehensive analysis of cerebellar interactions with the amygdala and prefrontal cortex during associative motor learning. Our general conceptual framework is that the cerebellum receives inputs from the amygdala and prefrontal cortex via the pons regarding which stimuli are important and when they occur, and the cerebellum then sends error-driven feedback to these forebrain systems to facilitate learning about important events. This conceptual framework takes into account the bidirectional relationship between the cerebellum and the relevant forebrain systems as well as interactions between forebrain systems. Multi-site electrophysiology, pathway-specific optogenetics, and precise behavioral analyses will be combined to investigate circuit-level interactions between the cerebellum, amygdala, and prefrontal cortex during associative learning and extinction (inhibitory learning) training. The proposed studies would significantly advance understanding of the neural circuit mechanisms underlying cerebellar interactions with the forebrain. This would be a substantial contribution to the field because it has been known that the cerebellum must interact with the forebrain in many contexts that are crucial for everyday life such as learning, memory, planning, control of emotions, and communication, but very little is known mechanistically about how the cerebellum interacts with the amygdala and prefrontal cortex.

学习是有机体如何适应环境的变化，并涉及协调 调节认知、情绪和运动控制的神经系统。这次会议的主要目标是 建议的研究计划是阐明潜在的相互作用的神经回路机制 在联想学习过程中认知、情绪和运动系统之间的关系。互动 这些神经系统之间的关系尤为重要，因为环境和情感 刺激的意义为运动的获得和表现提供必要的信息 回应。认知、情绪和运动系统之间相互作用的崩溃 因此，各种神经疾病可能会对习得者造成毁灭性的后果 行为。前额叶皮质、杏仁核和小脑在认知中起着重要作用， 情绪反应和运动学习。建议的研究计划 构成了对小脑与杏仁核和前额叶相互作用的全面分析 在联想运动学习中的大脑皮层。我们的总体概念框架是 小脑通过脑桥接受来自杏仁核和前额叶皮质的信息输入 哪些刺激是重要的，以及它们何时发生，然后小脑发出错误驱动的信号 反馈给这些前脑系统，以促进对重要事件的学习。这 概念框架考虑了小脑之间的双向关系 以及相关的前脑系统以及前脑系统之间的相互作用。多站点 电生理学、特定路径的光遗传学和精确的行为分析将是 结合研究小脑、杏仁核和大脑皮质之间的电路水平的相互作用 联想学习和消退(抑制性学习)训练中的前额叶皮质。这个 提出的研究将大大促进对神经回路机制的理解 潜在的小脑与前脑的相互作用。这将是对 这是因为人们已经知道，在许多情况下，小脑必须与前脑相互作用 对日常生活至关重要的环境，如学习、记忆、计划、控制 情绪和交流，但对小脑如何机制知之甚少 与杏仁核和前额叶皮质相互作用。