Research on the substance in the brain involves in functional recovery by exercise after cerebral infarction
脑内物质参与脑梗塞后运动功能恢复的研究
基本信息
- 批准号:17300186
- 负责人:
- 金额:$ 8.26万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2005
- 资助国家:日本
- 起止时间:2005 至 2006
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To investigate he substance which promotes functional recovery after cerebral infarction, we conducted following experiments using rats with dhotochemically cerebral infarction. We evaluated performance according to Feeney's beam walking evaluation.1. We investigated the time course of functional recovery and the change in the expression of GDNF for 2 weeks. Functional recovery was prominent during first 1 week and GDNF-positive cells around the infarction were increased on a parallel with functional recovery.2. We investigated differences in functional recovery among beam walking exercise group, treadmill exercise group and natural course group for 2 weeks. Exercise groups recovered earlier than natural course group and beam walking exercise was more effective than treadmill exercise. These results suggest that the exercise promotes functional recovery and advanced exercise is more effective than simple exercise.3. We investigated functional recovery following second contralateral infarction. Following first infarction, rats recovered nearly equal to normal level after 2 weeks. But following second contralateral infarction, functional recovery stayed low level after 2 weeks. These results indicate that contralateral cortex is important in functional recovery after cerebral infarction.4. We investigated the effect of edaravone on functional recovery, infarct size, and the expression of caspase. Intraperitoneal injection of edaravone for 1 weeks reduced infarct size and promoted functional recovery and the expression of caspase-positive cells in the border of infarct area increased 24 hours after injection. These results suggest that edaravone expands penumbra area leading to the reduction of infarct size and the promotion of functional recovery.
To investigate he substance which promotes functional recovery after cerebral infarction, we conducted following experiments using rats with dhotochemically cerebral infarction. We evaluated performance according to Feeney's beam walking evaluation.1. We investigated the time course of functional recovery and the change in the expression of GDNF for 2 weeks. Functional recovery was prominent during first 1 week and GDNF-positive cells around the infarction were increased on a parallel with functional recovery.2. We investigated differences in functional recovery among beam walking exercise group, treadmill exercise group and natural course group for 2 weeks. Exercise groups recovered earlier than natural course group and beam walking exercise was more effective than treadmill exercise. These results suggest that the exercise promotes functional recovery and advanced exercise is more effective than simple exercise.3. We investigated functional recovery following second contralateral infarction. Following first infarction, rats recovered nearly equal to normal level after 2 weeks. But following second contralateral infarction, functional recovery stayed low level after 2 weeks. These results indicate that contralateral cortex is important in functional recovery after cerebral infarction.4. We investigated the effect of edaravone on functional recovery, infarct size, and the expression of caspase. Intraperitoneal injection of edaravone for 1 weeks reduced infarct size and promoted functional recovery and the expression of caspase-positive cells in the border of infarct area increased 24 hours after injection. These results suggest that edaravone expands penumbra area leading to the reduction of infarct size and the promotion of functional recovery.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
New Facilitation exercise using the vestiburo-ocular reflex for opthalmoplesia : preliminary report.
使用前庭眼反射治疗眼肌麻痹的新促进练习:初步报告。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:藤田翔平;村山愛;林豊彦;中村康雄;小島英敏;道見登;Kawahira K et al.
- 通讯作者:Kawahira K et al.
Impaired visuo-motor skills in the unaffected lower limb of patients with stroke
- DOI:10.1080/00207450590934561
- 发表时间:2005-09-01
- 期刊:
- 影响因子:2.2
- 作者:Kawahira, K;Shimodozono, M;Tsujio, S
- 通讯作者:Tsujio, S
Evaluation of skilled leg movements in patients with stroke using a computerized motor-skill analyzer for lower limb.
使用计算机下肢运动技能分析仪评估中风患者的腿部熟练运动。
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:村山愛;林豊彦;中村康雄;道見登;Kawahira K et al.
- 通讯作者:Kawahira K et al.
Evaluation of skilled leg movements in patients with stroke usinga computerized motor-skill analyzer for lower limb.
使用计算机下肢运动技能分析仪评估中风患者的腿部熟练运动。
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:村山愛;林豊彦;中村康雄;道見登;Kawahira K et al.;Kawahira K et al.;角森 昭教;Kawahira K et al.;山村 宏明;松本 康夫;Kawahira K et al.
- 通讯作者:Kawahira K et al.
Functional recovery and expression of GDNF seen in photochemically induced cerebral infarction
- DOI:10.1080/00207450600582124
- 发表时间:2007-03-01
- 期刊:
- 影响因子:2.2
- 作者:Horinouchi, Keisuke;Ikeda, Satoshi;Kawahira, Kazumi
- 通讯作者:Kawahira, Kazumi
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KAWAHIRA Kazumi其他文献
New functional vibratory stimulation device for extremities in patients
用于患者四肢的新型功能性振动刺激装置
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
Kawahira;K.;Kawahira Kazumi;Kawahira Kazumi;KAWAHIRA Kazumi;KAWAHIRA Kazumi - 通讯作者:
KAWAHIRA Kazumi
KAWAHIRA Kazumi的其他文献
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{{ truncateString('KAWAHIRA Kazumi', 18)}}的其他基金
Studies of innovative gate training using repetition of facilitation exercise or functional vibratory stimulation for patients with hemiplegia
使用重复促进运动或功能性振动刺激对偏瘫患者进行创新门训练的研究
- 批准号:
22300190 - 财政年份:2010
- 资助金额:
$ 8.26万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Effect of Trans-cranial Magnetic Stimulation on Functional Recovery of Hemiplegia and Motor Learning ; Study Using of Motor Learning Task and Electrophysiological Methods.
经颅磁刺激对偏瘫功能恢复和运动学习的影响;
- 批准号:
15300206 - 财政年份:2003
- 资助金额:
$ 8.26万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of a Functional Recovery Training Assistant System of Hemiplegic Lower Limb; Motion Evaluation and Training System for the Hemiplegic Lower Limb and Its Clinical Application in Rehabilitation
偏瘫下肢功能恢复训练辅助系统的研制
- 批准号:
10838023 - 财政年份:1998
- 资助金额:
$ 8.26万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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