Effect of weight-bearing after autologous osteochondral grafting surgery on stiffness parameter of articular cartilage of the osteochondral plug and range of knee motion

自体骨软骨移植术后负重对骨软骨栓关节软骨刚度参数及膝关节活动范围的影响

• 批准号: 17300185
• 负责人: KUROKI Hiroshi
• 金额: $ 9万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300185/
• 关键词: Articular Cartilage; Autologous Osteochondral Transplantation; Ultrasound Stiffness Parameter; Weight Bearing; Range of Motion; 軟骨硬度; 超音波; 軟骨; 硬度; 家兎; 膝; 加齢

The osteochondral grafting surgery is often used for isolated cartilage lesions. Aim of this study was to investigate the effect of the surgery on articular cartilage of the osteochondral plug, bone healing and range of knee motion. Histology and ultrasound parameters of articular cartilage of the osteochondral plug were studied in the 6-mm model of rabbits. The rabbits were divided into two groups of the weight-bearing model and the non-weight-bearing model. The ultrasound stiffness parameter of articular 'cartilage of the plug decreased up to 12 weeks and then increased at 24 and 52 weeks after the surgery. Postoperative care for up to 12 weeks should be taken after the surgery. Part of this study has been publishedin 'Arthroscopy' and has been presented in the 2007 World Congress on Osteoarthritis.

骨软骨移植手术常用于孤立的软骨病变。本研究的目的是探讨手术对骨软骨栓塞的关节软骨、骨愈合和膝关节活动度的影响。在6 mm骨软骨栓模型上，对兔关节软骨进行组织学和超声参数的研究。将家兔分为负重模型组和非负重模型组。关节软骨超声硬度参数在术后12周下降，24周和52周上升。术后应进行长达12周的术后护理。这项研究的一部分已经在“关节镜检查”中得到证实，并在2007年世界骨关节炎大会上发表。

项目成果

Sequential changes in implanted cartilage after autologous osteochondral transplantation: postoperative

自体骨软骨移植后植入软骨的连续变化：术后

• 发表时间: 2007
• 期刊: Arthroscopy 23
• 作者: Kuroki H;Nakagawa Y;Mori K;Kobayashi M;Okamoto Y. Yasura
• 通讯作者: Okamoto Y. Yasura

Histological observations and ultrasound assessment of a fullthickness cartilage defect in 'a rabbit model

兔模型全层软骨缺损的组织学观察和超声评估

• 发表时间: 2007
• 作者: Hiroshi;Kuroki;Yasuaki;Nakagawa;Koji;Mori;Masahiko;Kobayashi;Yukihiro;Okamoto;Ko;Yasura;Kohei;Nishitani;Takashi;Nakamura
• 通讯作者: Nakamura

Sequential changes in implanted cartilage after autologous osteochondral transplantation: Postoperative acoustic properties up to 1 year in an in vivo rabbit model

• DOI: 10.1016/j.arthro.2007.01.012
• 发表时间: 2007-06-01
• 期刊: ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
• 影响因子: 4.7
• 作者: Kuroki, Hiroshi;Nakagawa, Yasuaki;Nakamura, Takashi
• 通讯作者: Nakamura, Takashi

Histological observations and ultrasound assessment of afullthickness cartilage defect in a rabbit model

兔模型全层软骨缺损的组织学观察和超声评估

• 发表时间: 2007
• 作者: Kuroki H;Nakagawa Y;Mori K;Kobayashi M;Okamoto Y;Yasura K;Nishitani K;Nakamura T
• 通讯作者: Nakamura T

Maturation-dependent change and regional variations in acoustic stiffness of rabbit articular cartilage: an examination of the superficial collagen-rich zone of cartilage

• DOI: 10.1016/j.joca.2006.02.001
• 发表时间: 2006-08-01
• 期刊: OSTEOARTHRITIS AND CARTILAGE
• 影响因子: 7
• 作者: Kuroki, H.;Nakagawa, Y.;Nakamura, T.
• 通讯作者: Nakamura, T.