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Study of oxygen transport in tissue using reflection type diffuse optical tomography

利用反射型漫射光学断层扫描研究组织中的氧传输

基本信息

批准号：
17360095
负责人：
YAMADA Yukio
金额：
$ 5.25万
依托单位：
The University of Electro-Communications
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17360095/
关键词：
Diffuse Optical Tomography near infrared light time-resolved measurement inverse problem higher brain function optical mapping 脳の高次機能光学ファントム

项目摘要

Study of transport phenomena in human body is essential to understand the complex physiological mechanisms in living organisms. In recent years, noninvasive monitoring of hemodynamics using near infrared (NIR) light has been gaining the attention. NIR light diffusively propagates through biological tissues, and its absorption spectrum varies with blood oxygenation. These allow us Diffuse Optical Tomography (DOT) which can illustrate the spatial distribution of the hemoglobin concentrations within the tissues. This study intended to unveil the hemodynamics in the brain and muscles with DOT.Simple DOT systems using continuous-light can generate tomographic images when transmitted light through the object is detectable. However, it is difficult to obtain images only from the data of the reflected light when the transmitted light is undetectable due to the large size of the object. Pico-second time resolved measurement makes it possible to obtain tomographic images from reflected light. We attempted to monitor the hemodynamics in an adult brain with reflection-type DOT using a pico-second time-resolved measurement system, and discussed the related issues as well.The major achievements of this study are as the following :(i) It is proven by the numerical simulation and in vivo experiments that reflection-type DOT images can be obtained by a pico-second time resolved measurement system in the case of large objects such as an adult head through which the transmitted light is undetectable. (ii) It is found that the precise measurement of the positions of the source-detector optical fibers attached on the skin of the subject is essential for high-quality imaging. (iii) The DOT images of the oxygenation and blood volume in frontal lobe during calculation tasks were obtained. (iv) Optical mapping using the reflected light data is found to be affected by the structure of the head, especially by the cerebrospinal fluid and the skull layers.

研究人体运输现象对于理解生物体复杂的生理机制至关重要。近年来，利用近红外（NIR）光进行无创血流动力学监测已引起人们的关注。近红外光在生物组织中扩散传播，其吸收光谱随血液氧合变化。这些使我们能够使用漫反射光学断层扫描（DOT）来说明组织内血红蛋白浓度的空间分布。这项研究旨在通过 DOT 揭示大脑和肌肉的血流动力学。当可检测到穿过物体的透射光时，使用连续光的简单 DOT 系统可以生成断层扫描图像。然而，当由于物体尺寸较大而无法检测到透射光时，仅从反射光数据获得图像是很困难的。皮秒时间分辨测量使得从反射光获取断层图像成为可能。我们尝试利用皮秒时间分辨测量系统对成人大脑中的反射型DOT进行血流动力学监测，并讨论了相关问题。本研究的主要成果如下：(i)通过数值模拟和活体实验证明，皮秒时间分辨测量系统可以在该案例中获得反射型DOT图像。大型物体，例如成人头部，透过该物体无法检测到透射光。（ii）人们发现，精确测量附着在受试者皮肤上的源探测器光纤的位置对于高质量成像至关重要。 (iii) 获得计算任务期间额叶氧合和血容量的 DOT 图像。（iv）发现使用反射光数据的光学测绘受到头部结构的影响，尤其是脑脊液和颅骨层的影响。