Effects of mechanical stress on bone metabolism and life span in stroke-prone spontaneously hypertensive rats

机械应力对脑卒中易发性高血压大鼠骨代谢和寿命的影响

• 批准号: 17500446
• 负责人: UMEMURA Yoshihisa
• 金额: $ 2.22万
• 依托单位: Chukyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500446/
• 关键词: Mechanical Stress; Bone Mineral Density; Hypertension; Cerebral Apoplexy; Osteopontin; Osteocalcin; オステオプロテゲリン

I investigated the effects of jump exercise on calcium metabolism and life span in stroke-prone spontaneously hypertensive rats(SHRSP). It was reported SHRSP became hypertension as they grew and was died by cerebral apoplexy, and they also had abnormal calcium metabolism. It was assumed that the abnormal calcium metabolism was one of important factors of their vascular disease. On the other hand, in my previous study, jump exercise in rats effectively gained calcium accumulation in regional bones. Thus, I assumed that jump exercise influenced whole body calcium metabolism in SHRSP.Firstly, I investigated the effect of jump exercise on life span in SHRSP. Although I tried twice, I did not find significant difference in life span between exercised and sedentary group.Secondly, I investigated the effect of jump exercise on calcium metabolism in SHRSP. Jump exercise increased bone mass of lower limb in SHRSP like in normal rats. However, jump exercise did not affect serum calcium and parathyroid hormone although it significantly decreased serum phosphate in SHRSP. These results suggested that jump exercise did not alter whole body calcium metabolism.Thirdly, I investigated the effect of jump exercise on serum cytokine or protein level associated with osteocyte in SHRSP or normal rats. I did not find significant changes in osteopontin, sRANKL, matrix Gla protein and osteoprotegerin in exercised SHRSP or normal rats. I also measured lipid metabolism but also did not find the significant influences of jump exercise. In conclusion, jump exercise in SHRSP did not change whole body calcium metabolism although it increase local bone mass. It also did not influence life span in SHRSP.

我研究了跳跃运动对卒中易感型自发性高血压大鼠(SHRSP)钙代谢和寿命的影响。据报道，SHRSP随着生长发育成高血压，并死于中风，同时他们还存在钙代谢异常。推测钙代谢异常是其发生血管疾病的重要因素之一。另一方面，在我之前的研究中，跳跃运动有效地增加了大鼠局部骨骼中的钙积累。因此，我认为跳跃运动影响了SHRSP的全身钙代谢。首先，我研究了跳跃运动对SHRSP寿命的影响。虽然我尝试了两次，但我没有发现运动组和静坐组的寿命有显著差异。第二，我研究了跳跃运动对SHRSP患者钙代谢的影响。跳跃运动增加SHRSP类正常大鼠的双腿骨量。跳跃运动虽能显著降低SHRSP患者的血磷水平，但对血钙和甲状旁腺激素无明显影响。这些结果提示跳跃运动不会改变全身钙代谢。第三，观察跳跃运动对SHRSP和正常大鼠血清中与骨细胞相关的细胞因子或蛋白水平的影响。运动后SHRSP和正常大鼠的骨桥蛋白、sRANKL、基质GLA蛋白和护骨素均未见明显变化。我还测量了脂代谢，但也没有发现跳跃运动的显着影响。综上所述，SHRSP跳跃运动虽然增加了局部骨量，但并未改变全身钙代谢。也不影响SHRSP的寿命。

项目成果

Effect of jump exercise on serum lipid in osteopenic ovariectomized rats

跳跃运动对去势骨质疏松大鼠血脂的影响

• 发表时间: 2007
• 期刊: Bulletin of Research Institute of Health and Sport Science, Chukyo University
• 作者: Umemura;Y
• 通讯作者: Y

ハイインパクトトレーニングは卵巣摘出ラットの骨面積を増大させ、その効果は脱トレーニング後も維持される

高强度训练增加了去势大鼠的骨面积，并且即使在停止训练后效果仍然保持

• 发表时间: 2006
• 作者: 梅村義久;松本実;垂井彩未;山根基;十河直太;梅村 義久
• 通讯作者: 梅村 義久

雄性ラットにおけるジャンプトレーニングが血清オステオカルシンに及ぼす影響

跳跃训练对雄性大鼠血清骨钙素的影响

• 发表时间: 2006
• 期刊: 中京大学体育研究所紀要 20
• 作者: Umemura;Y;梅村義久;梅村 義久
• 通讯作者: 梅村 義久

High-impact training increased bone area in ovariectomized rats, and the training effect were preserved after detraining

高强度训练增加了去势大鼠的骨面积，并且训练效果在停止训练后得以保留

• 发表时间: 2006
• 作者: Umemura;Y
• 通讯作者: Y

Effects of jump training on bone are preserved after detraining regard-less of estrogen secretion state in rats

无论大鼠雌激素分泌状态如何，跳跃训练对骨骼的影响在停止训练后仍然保留

• 发表时间: 2008
• 期刊: Journal of Applied Physiology 104
• 作者: MUNEHIKO HARADA;KAZUHIKO KIMURA;木村和彦;KAZUHIKO KIMURA;木村和彦;KAZUHIKO KIMURA;原田宗彦・木村和彦編著;梅村 義久;Umemura Y
• 通讯作者: Umemura Y