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Analysis for the pathogenesis of HHV-6 encephalitis in transplant recipients and establishment of guideline for the treatment

移植受者HHV-6脑炎发病机制分析及治疗指南的制定

基本信息

批准号：
17591120
负责人：
YOSHIKAWA Tetsushi
金额：
$ 2.39万
依托单位：
Fujita Health University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591120/
关键词：
HHV-6 HSCT reactivation encephalitis cytokine 造血肝細胞移植

项目摘要

Although it has been demonstrated that human herpesvirus 6 (HHV-6) reactivation generally occurs approximately 2 to 3 weeks after transplantation in the hematopoietic stem cell transplantation (HSCT) recipients, the mechanism, of viral reactivation remains unclear. To explore the relationship between HHV-6 reactivation and plasma cytokine levels, 24 HSCT recipients underwent measurements of plasma proinflammatory cytokine levels (IL-6, TNF-α, IL-lβ, and IFN-Y), viral isolation, and serological assays. Of these patients, 14 developed an HHV-6 reactivation, and 9 developed HHV-6 viremia approximately 2 to 3 weeks after transplantation. IL-6 levels were significantly higher in the recipients with an HHV-6 reactivation than in the subjects without an HHV-6 reactivation at 1 week, 2 Weeks, and 4 weeks after transplantation. In addition, the level of TNF-α was significantly higher in recipients with an HHV-6 reactivation than in those without an HHV-6 reactivation at 2 weeks post-transplantation. Low levels of IL-1β and IFN-Y were detected in small number of the plasma samples, although there were no significant differences between the two groups in the levels of these cytokines. These results imply that proinflammatory cytokines, in particular IL-6 and TNF-α, play a role in the pathogenesis of HHV-6 reactivation after HSCT.

虽然已经证明，人疱疹病毒6型（HHV-6）的再激活通常发生在造血干细胞移植（HSCT）受者的移植后约2至3周，但病毒再激活的机制仍不清楚。为探讨HHV-6再活化与血浆细胞因子水平的关系，对24例HSCT受者进行了血浆促炎细胞因子水平（IL-6、TNF-α、IL-1 β和IFN-γ）、病毒分离和血清学测定。在这些患者中，14例在移植后约2至3周发生HHV-6再活化，9例发生HHV-6病毒血症。在移植后1周、2周和4周，HHV-6再激活的受者中的IL-6水平显著高于没有HHV-6再激活的受试者。此外，移植后2周，HHV-6再激活的受者的TNF-α水平显著高于未激活的受者。在少数血浆样本中检测到低水平的IL-1β和IFN-γ，尽管两组之间这些细胞因子的水平没有显著差异。这些结果表明，促炎细胞因子，特别是IL-6和TNF-α，在HSCT后HHV-6再活化的发病机制中起作用。