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Analysis of pathogenesis of HHV-6 encephalitis at the time of primary infection and reactivation of the virus

HHV-6脑炎初次感染及病毒再激活时的发病机制分析

基本信息

批准号：
20591290
负责人：
YOSHIKAWA Tetsushi
金额：
$ 3万
依托单位：
Fujita Health University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591290/
关键词：
HHV-6 初感染移植後脳炎サイトカイン再活性化移植脳炎

项目摘要

Background : Pathogenesis of human herpesvirus 6 (HHV-6) encephalitis, in particular difference between HHV-6 encephalitis at the time of primary infection and reactivation remains unclear.Objectives : To elucidate the mechanism of HHV-6 encephalitis at the time of primary infection and reactivation.Study design : Twenty-two HHV-6 encephalitis patients at the time of primary infection, 6 febrile convulsion (FC) patients caused by HHV-6 infection, and 14 FC patients without HHV-6 infection (non HHV-6 FC) were enrolled. Additionally, 7 stem cell transplant recipients with HHV-6 encephalitis and eight adult controls were also enrolled in this study. Cerebrospinal fluid (CSF) HHV-6 DNA copy numbers and biomarkers levels were compared.Results : Low copy number of CSF HHV-6 DNA was detected in 7 of the 22 patients with HHV-6 encephalitis in primary infection, whereas all seven CSF samples collected from post-transplant HHV-6 encephalitis patients contained high viral DNA copy numbers (P<0.001). CSF concentrations of IL-6 (P=0.032), IL-8 (P=0.014), MMP-9 (P=0.004), and TIMP-1 (P=0.002) were significantly higher inpatients with HHV-6 encephalitis in primary infection than non-HHV-6 FC. CSF IL-6 (P=0.008), IL-8 (P=0.015), and IL-10 (P=0.019) concentrations were significantly higher in patients with post-transplant HHV-6 encephalitis than adult controls.Conclusion : The present study suggests that the characteristics of HHV-6 encephalitis is different between HHV-6 encephalitis at the time of primary infection and reactivation in transplant recipients.

背景资料：人类疱疹病毒6型（HHV-6）脑炎的发病机制，特别是HHV-6脑炎在初次感染和再激活时的差异仍不清楚。目的：阐明HHV-6脑炎在初次感染和再激活时的机制。22例HHV-6脑炎患者在初次感染时，6例HHV-6感染引起的热性惊厥（FC）患者，14例无HHV-6感染的FC患者（非HHV-6 FC）入组。此外，7名患有HHV-6脑炎的干细胞移植受者和8名成人对照也入组本研究。结果：22例HHV-6脑炎患者中，7例HHV-6脑炎患者脑脊液中HHV-6 DNA拷贝数较低，7例移植后HHV-6脑炎患者脑脊液中HHV-6 DNA拷贝数均较高（P<0.001）。HHV-6脑炎患者CSF中IL-6（P=0.032）、IL-8（P=0.014）、MMP-9（P=0.004）和TIMP-1（P=0.002）浓度显著高于非HHV-6 FC患者。CSF IL-6（P=0.008），IL-8（P=0.015），IL-10（P=0.019）浓度显着高于移植后HHV-6脑炎患者比成人controls.Conclusion：本研究表明，HHV-6脑炎的特点是不同的HHV-6脑炎在移植受者的初次感染和再激活的时间。