A THERAPEUTIC RESEARCH IN THE PATIENTS WITH ESTROGEN RECEPTOR EXPRESSING TUMOR USING POSITRON EMISSION TOMOGRAPHY

正电子发射断层扫描对雌激素受体表达肿瘤的治疗研究

• 批准号: 17591280
• 负责人: KANEKO Koichiro
• 金额: $ 2.6万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591280/
• 关键词: Diagnostic image; Cancer; Positron emission tomography; Estrogen receptor; Stratification of therapeutic method

Title: EFFECTS OF HORMONE THERAPY IN PATIENTS WITH ESTROGEN RECEPTOR-EXPRESSINGTUMORS: A STUDY USING POSITRON EMISSION TOMOGRAPHY[Summary]We studied the effects of hormone therapy in patients with estrogenreceptor-expressing tumors using FDG-and FES-based positron emission tomography (PET). In the FDG-PET trials, FDG accumulation did not correlate with estrogen receptor expression, but did correlate with tumor size in the 9 breast cancer patients studied. In the 6 recurrent malignant melanoma patients, FDG accumulation did not correlate with the effects of the DAC-Tam method, which was the chemotherapy protocol combined with the estrogen blocker tamoxifen.Next, we evaluated the correlation between FES-PET findings and the therapeutic effect in three breast cancer patients. In all three cases, estrogen receptors were expressed in the primary sites and all patients had multiple metastatic sites. In two cases, the FES accumulation was different for each metastatic site; for example, high … More FES accumulation was observed in brain metastases, but no accumulation was observed in bone metastases. In one bone metastases patient without FES accumulation, hormone therapy was not effective, and resulted in much more advanced bone metastases after six months. It was suggested that the effects of hormone therapy may differ according to metastatic site, even if estrogen receptors are expressed at the same primary site. In one case with high FES accumulation in all metastatic sites, hormone therapy was effective. After one year, tumor marker ST 439 was almost normalized in this patient. We investigated the correlation between FES-PET findings and FDG-PET findings in two cases of breast cancer.FDG accumulation was observed in all metastatic sites in both patients; however, hormone therapy was effective in the one FES-positive case but not in the other FES-negative case.In conclusion, it appeared that FES-PET but not FDG-PET may be useful to predict the effects of hormone therapy. Further examinations with larger numbers of patients are required to clarify the role of FES-PET. Less

职务名称：雌激素受体表达肿瘤患者激素治疗的效果：一项使用正电子发射断层扫描的研究[摘要]我们使用基于FDG和FES的正电子发射断层扫描（PET）研究了雌激素受体表达肿瘤患者激素治疗的效果。在FDG-PET试验中，FDG蓄积与雌激素受体表达无关，但与研究的9例乳腺癌患者的肿瘤大小相关。在6例复发性恶性黑色素瘤患者中，FDG蓄积与DAC-Tam方法的疗效无关，DAC-Tam方法是联合雌激素阻断剂他莫昔芬的化疗方案。接下来，我们评估了3例乳腺癌患者的FES-PET结果与治疗效果的相关性。在所有三个病例中，雌激素受体在原发部位表达，所有患者都有多个转移部位。在两种情况下，每个转移部位的FES积累是不同的;例如，高FES积累是高转移部位。 ...更多信息 在脑转移瘤中观察到FES蓄积，但在骨转移瘤中未观察到蓄积。在一名没有FES积聚的骨转移患者中，激素治疗无效，并在六个月后导致更晚期的骨转移。这表明，激素治疗的效果可能会有所不同，根据转移部位，即使雌激素受体表达在相同的原发部位。1例FES在所有转移部位均有高蓄积，激素治疗有效。一年后，该患者的肿瘤标志物ST 439几乎正常化。我们研究了两例乳腺癌患者的FES-PET和FDG-PET结果之间的相关性。在这两例患者的所有转移部位均观察到FDG积聚;然而，激素治疗在一例FES阳性的病例中有效，而在另一例FES阴性的病例中无效。总之，FES-PET而不是FDG-PET可能有助于预测激素治疗的效果。需要对更多患者进行进一步检查，以阐明FES-PET的作用。少

项目成果

Usefulness of FES-PET for the diagnosis and prediction of the response to hormone therapy in a case of recurrent breast cancer patient

FES-PET 在复发性乳腺癌患者的诊断和激素治疗反应预测中的作用

• 发表时间: 2007
• 作者: Hirofumi;Sawamoto;Hirofumi;Koga;Koichiro;Abe;Koichiro;Kaneko;Hiroshi;Honda;Masayuki;Sasaki;Noriaki;Sadanaga;Satoshi;Fukuyama
• 通讯作者: Fukuyama

FES-PETが診断及び治療効果予測に有用であった再発乳癌の一例

FES-PET 有助于诊断和预测治疗效果的复发性乳腺癌一例

• 发表时间: 2007
• 作者: 澤本 博史、金子 恒一郎;ら
• 通讯作者: ら