Evaluation of prospective clinical research on aptitude for photocoagulation therapy of diabetic retinopathy

糖尿病视网膜病变光凝治疗适应性的前瞻性临床研究评价

• 批准号: 17591856
• 负责人: HORI Sadao
• 金额: $ 2.37万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591856/
• 关键词: diabetic retinopathy; photocoagulation; randomized clinical trial; 多施設臨床研究; prospective clinical study

To evaluate the efficacy of timing and method of photocoagulation for pre-proliferative diabetic retinopathy, treated group and non-treated group were compared at 36 months after randomized prospective clinical trial.Forty nine eyes were involved in the study with moderately severe pre-proliferative diabetic retinopathy and randomly divided into two groups; 23 eyes for treated group and 26 for non-treated, the eyes followed more than 36 months were 12 in the treated eyes and 20 in the non-treated eyes. In the treated group, selective photocoagulation was performed at the beginning of the trial to the non-perfused areas detected by fluorescein angiography (FAG). Additional coagulation was performed when the non-perfused area was progressed and detected at periodical examinations after the selective coagulation. In the non-treated group, scattered coagulation was performed when the neovascularization (NV) was detected by FAG at every 6-months examination.At 36 months, 2 eyes developed NV in the treated group whereas 12 eyes in the non-treated group (p=0.02). When the visual acuity was compared between the baseline and at 36months, it reduced more than 2 lines in the treated group (p=0.047) and no reduction of visual acuity was noted in the non-treated group.The photocoagulation was recommended for the moderately severe pre-proliferative diabetic retinopathy to prevent progression of proliferative diabetic retinopathy.

为评价光凝治疗增殖期前糖尿病视网膜病变的时机和方法，在随机前瞻性临床试验结束后36个月，对治疗组和非治疗组进行比较。治疗组23眼，非治疗组26眼，随访36个月以上者治疗组12眼，非治疗组20眼。在治疗组中，在试验开始时对荧光素血管造影（FAG）检测到的非灌注区进行选择性光凝。当非灌注区进展并在选择性凝固后定期检查时检测到时，进行额外的凝固。在非治疗组中，每6个月检查一次，当FAG检测到新生血管（NV）时，进行散在凝固。在36个月时，治疗组中有2只眼发生NV，而非治疗组中有12只眼发生NV（p=0.02）。治疗组视力较治疗前下降2行以上（p=0.047），未治疗组视力无下降，建议对中重度增殖期前糖尿病视网膜病变患者行光凝治疗，以防止增殖期糖尿病视网膜病变的进展。

项目成果

Tracing method in the assessment of retinal capillary blood flow velocity by fluorescein angiography with scanning laser ophthalmoscope

扫描激光检眼镜荧光血管造影评估视网膜毛细血管血流速度的追踪方法

• 发表时间: 2006
• 期刊: Jpn J Ophthalmol 50
• 作者: Funatsu H;Sakata K;Harino S;Okuzawa Y;Noma H;Hori S
• 通讯作者: Hori S

Relationship between macular microcirculation and progression of diabetic macular edema

• DOI: 10.1016/j.ophtha.2006.04.023
• 发表时间: 2006-08-01
• 期刊: OPHTHALMOLOGY
• 影响因子: 13.7
• 作者: Sakata, Kumi;Funatsu, Hideharu;Hori, Sadao
• 通讯作者: Hori, Sadao

Effect of perioperative glycemic control in progression of diabetic reti nopathy and maculopathy

围手术期血糖控制对糖尿病视网膜病变和黄斑病变进展的影响

• 发表时间: 2006
• 期刊: Arch Ophthalmol 124
• 作者: Suto C;Hori S;Kato S;Muraoka K;Kitano S
• 通讯作者: Kitano S

Effect of perioperative glycemic control in progression of diabetic r etinopathy and maculopathy

围手术期血糖控制对糖尿病视网膜病变和黄斑病变进展的影响

• 发表时间: 2006
• 期刊: Arch Ophthalmol 124
• 作者: Suto C;Hori S;Kato S;Muraoka K;Kitano S
• 通讯作者: Kitano S

Effect of perioperative glycemic control in progression of diabetic retinopathy and maculoathy

围手术期血糖控制对糖尿病视网膜病变和黄斑病变进展的影响

• 发表时间: 2006
• 期刊: Arch Ophthalmol 124
• 作者: Suto C;Hori S;Kato S;Muraoka K;Kitano S
• 通讯作者: Kitano S