Basic study about cell-based therapy by cell life span control using human papillomavirus

利用人乳头瘤病毒控制细胞寿命的细胞疗法的基础研究

• 批准号: 17591931
• 负责人: TERAI Masanori
• 金额: $ 2.56万
• 依托单位: National Research Institute for Child Health and Development
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591931/
• 关键词: 再生医学; 細胞・組織; ウイルス

臍帯血からの間葉系細胞のstrainの樹立さらに寿命を延長することに成功し、それぞれの細胞の特徴性格づけも行った。さらに月経血からの間葉系細胞の骨格筋への高率な分化誘導にも成功した。この技術はヒト正常体細胞を用いた将来の細胞移植治療の応用の際に大きな利益をもたらすと考える。

The establishment of the umbilical cord mesenchymal cells was successful, and the characteristics of the cells were not affected. A high rate of differentiation of mesenchymal cells was successfully induced. This technique is useful in the treatment of normal somatic cells and in the treatment of future cell transplants.

项目成果

Diversifying selection in human papillomavirus type 16 (HPV16) lineages based on complete genome analysis.

基于完整基因组分析的人乳头瘤病毒 16 型 (HPV16) 谱系的多样化选择。

• 发表时间: 2005
• 期刊: Journal of Virology 79
• 作者: Chen Z;Terai M;Fu L;Herrero R;DeSalle R;Burk RD.
• 通讯作者: Burk RD.

いぼの分子、細胞生物学

疣的分子和细胞生物学

• 发表时间: 2005
• 期刊: Monthly Book Derma 97
• 作者: 寺井政憲;清野 透
• 通讯作者: 清野 透

Immortalization of human fetal cells : The life span of umbilical-cord-blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Joint Congress of "the 45th Annual Meeting of the Japanese Society for Artificial Organs" and "th

人类胎儿细胞的永生化：无需操纵 p16INK4a/RB 制动途径即可延长脐带血来源细胞的寿命。

• 发表时间: 2007
• 作者: 寺井政憲;他;Terai M.
• 通讯作者: Terai M.

Immortalization of human fetal cells:: The life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway

• DOI: 10.1091/mbc.e04-07-0652
• 发表时间: 2005-03-01
• 期刊: MOLECULAR BIOLOGY OF THE CELL
• 影响因子: 3.3
• 作者: Terai, M;Uyama, T;Kiyono, T
• 通讯作者: Kiyono, T

A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells.

• 发表时间: 2007
• 期刊: American journal of physiology. Gastrointestinal and liver physiology
• 作者: Y. Yoshida;T. Shimomura;Tomohiko Sakabe;K. Ishii;K. Gonda;Saori Matsuoka;Yumi Watanabe;Kazuko Takubo;H. Tsuchiya;Y. Hoshikawa;A. Kurimasa;I. Hisatome;T. Uyama;M. Terai;A. Umezawa;G. Shiota