Etiology and treatments for gingivitis and gingival overgrowth of the patients with cerebral palsy

脑瘫患者牙龈炎、牙龈增生的病因及治疗

• 批准号: 17592156
• 负责人: ITO Masaki
• 金额: $ 2.23万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17592156/
• 关键词: dentistry; gingival overgrowth; cerebral palsy; electron microscope

IntroductionThe patients with cerebral palsy often take anticonvulsants such as phenytoin (PHT). It is widely accepted that PHT induces gingival overgrowth and reduces bone growth. Oppositely an adverse effect such as calvarial thickening is reported. On the other hand, the parathyroid gland is deeply related to calcium metabolism. The purpose of this research project is to clarify the mechanism of PHT for the gingiva and the parathyroid gland by using electron microscope and establish effective prevention and treatment of PHT-induced gingival overgrowth.Materials and MethodsThis research project consisted of three parts. First, the investigators used electron microscope to observe the resected gingiva from the cerebral palsy patients who were given PHT. Secondly, we investigated to use PHT-induced rats. Their gingiva and the parathyroid glands were observed by electron microscope and body weights, serum phosphate, calcium and PHT concentrations were measured. Finally, we evaluated the relationship between oral hygiene management and fever of the patients in the institution for the patients with severe motor and intellectual disabilities.ResultsThe collagen fibers were increased in the hyperplastic gingiva of the cerebral palsy patients. The numbers and areas of the gingival fibroblasts were also increased in the findings of electron microscope.The mean body weight of PHT-induced rats was significantly less than control rats. The serum phosphate and calcium concentrations of PHT-induced rats were significantly lower than controls. In morphological study by electron microscope, the areas of Golgi apparatus and rough-surfaced endoplasmic reticulum (rough ER) in the gingival fibroblasts of PHT-induced rats significantly decreased compared with controls.During oral hygiene management by the dental profession, fever up of the severe cerebral palsy patients got decreased in the institution.

前言脑性瘫痪患者常服用苯妥英钠（PHT）等抗惊厥药物。PHT诱导牙龈过度生长并减少骨生长已被广泛接受。据报道，Opalone会产生不良反应，如颅骨增厚。另一方面，甲状旁腺与钙代谢密切相关。本研究项目的目的是通过电子显微镜阐明PHT对牙龈和甲状旁腺的作用机制，并建立有效的预防和治疗PHT引起的牙龈过度生长。首先，研究者用电子显微镜观察了脑瘫患者接受PHT治疗后切除的牙龈。第二，我们研究了使用PTH诱导的大鼠。用电镜观察牙龈和甲状旁腺，并测定体重、血清磷、钙和PHT浓度。最后，我们评估了口腔卫生管理和发热的患者在该机构的严重的运动和智力disability.ResultsThe胶原纤维的脑瘫患者的增生牙龈的关系。电镜下可见牙龈成纤维细胞数量增多，面积增大，平均体重明显低于对照组。血清磷和钙浓度显着低于对照组。电镜形态学观察发现，与对照组相比，PTH诱导的大鼠牙龈成纤维细胞中高尔基体和粗面内质网（rough-surfaced endoplasmic reticulum，rough-ER）面积明显减少。

项目成果

重症心身障害児施設における口腔保健管理 第3報

严重精神和身体残疾儿童设施中的口腔健康管理第3部分

• 发表时间: 2006
• 作者: 山内 香代子;他
• 通讯作者: 他

重症心身障害児施設における口腔保健管理 第3報歯周病原菌検査および歯周疾患所見

严重精神和身体残疾儿童设施中的口腔健康管理第3部分牙周病原菌检测和牙周病发现

• 发表时间: 2006
• 期刊: 日本障害者歯科学会誌 27(3)
• 作者: 山内香代子;伊藤正樹;平岡俊章・他
• 通讯作者: 平岡俊章・他

愛知学院大学歯学部附属病院障害者歯科診療部開設4年における初診患者の調査

爱知学院大学齿科医院残障牙科诊所开业第4年首次就诊患者的调查

• 发表时间: 2006
• 期刊: 愛院大歯誌 44
• 作者: 岡本 卓真;他
• 通讯作者: 他

A survey on first visit patients spanning 4 years since establishment of the clinic of dentistry for persons with disabilities of Aichi-Gakuin University Dental Hoapital.

爱知学院大学牙科医院残疾人牙科诊所成立以来 4 年期间首次就诊患者的调查。

• 发表时间: 2006
• 期刊: The Aichi-Gakuin Journal of Dental Science 44(2)
• 作者: Okamoto;T.;Hiraoka;T.;Oka;Y. Ito;M.
• 通讯作者: M.

The relationship between oral hygiene management and fever of the patients with severe motor and intellectual disabilities.

严重运动智力障碍患者口腔卫生管理与发热的关系

• 发表时间: 2008
• 期刊: Journal of the Japanese Society for Disability and Oral Health(in press) 29(2)
• 作者: Hiraoka;T.;Yamauchi;K.;Ito;M.;Okamoto;T.
• 通讯作者: T.