Dose the mast cell -dependent activation of the secretion of stress hormone potentially help to save the life of an allergic individual

结节部和正中隆起可见大量肥大细胞。当这些脑肥大细胞通过脑室内或静脉途径被动地接受免疫球蛋白E致敏时，肾上腺皮质醇和肾上腺素分泌明显增加，这是由随后的抗原刺激引起的（无论是通过中枢途径还是外周途径）。化合物48/80 （C48/80）是一种肥大细胞促分泌剂，当脑室内给药时，不仅能增加肾上腺皮质醇和肾上腺素的分泌，还能增加血浆肾素活性和血浆ADH水平。切除膈下双侧内脏神经完全阻止ige或c48 /80诱导的PRA和肾上腺素升高，但不能阻止皮质醇和ADH升高。酮替芬（肥大细胞稳定药物，实验前口服1周）可显著降低IgE-和c48 /80诱导的此类体液因子的增加。抗促肾上腺皮质激素释放因子抗体或组胺H^1阻滞剂预处理可减弱脑室内给予此类激素和肾素的肥大细胞依赖性增加。相反，脑室内给予组胺H^2阻滞剂预处理可增强这些物质的肥大细胞依赖性增加。这些数据表明，在狗中，脑肥大细胞的脱颗粒通过中枢释放组胺和下丘脑促肾上腺皮质激素释放因子引起垂体-肾上腺和/或交感-肾和肾上腺髓反应。基于这些数据，我们认为大脑肥大细胞可能起着过敏原传感器的作用。此外，我们认为，脑肥大细胞依赖性肾上腺皮质分泌和血管活性物质的增加，不仅可以改善超免疫反应的影响，还可以改善心血管和呼吸功能障碍的影响，从而可能有助于挽救个体的生命，否则在i型过敏爆发期间会发生这种反应。少

A large number of mast cells were found in the pars tuberalis and median eminence. When these brain mast cells were passively sensitized with immunoglobulin E via either the intracerebroventricular or intravenous route, there were marked increases in the adrenal cortisol and epinephrine secretion elicited by a subsequent antigenic challenge (whether this was delivered via the central or peripheral route). Compound48/80 (C48/80), a mast cell secretagogue, increased not only cortisol and epinephrine secretion from the adrenal glands but also increased plasma renin activity and plasma level of ADH when administered intracerebroventricularly. Resection of the bilateral splanchnic nerves below the diaphragm completely prevents the IgE-or C48/80-induced increases in PRA and epinephrine, but not increases in cortisol and ADH. Ketotifen (mast cells-stabilizing drug; given orally for 1 wk before the experiment)significantly reduced both of the IgE- and C48/80-induced increases in such humoral f … More actors. Pretreatment with anti-corticotropin-releasing factor antibodies or a histamine H^1-blocker attenuated the mast cell-dependent increases in such hormones and renin when given intracerebroventricularly. In contrast, pretreatment with a histamine H^2-blocker given intracerebroventricularly potentiated the mast celldependent increases in these substances. These data show that in the dog, degranulation of brain mast cells evokes the pituitary-adrenal and/or sympathetic-renal & adrenomedullary responses via centrally released histamine and hypothalamic corticotropin-releasing factor. On the basis of these data, we suggest that brain mast cells may act as an allergen sensor. Furthermore, we suggest that the brain mast cells-dependent increases in adrenocortical secretion and vasoactive substances could potentially help to save the life of an individual by ameliorating the effects of the not only hyper-immune reactions but also cardiovascular and respiratory dysfunction that would otherwise occur during an outbreak of type-I allergy. Less