权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Dose the mast cell -dependent activation of the secretion of stress hormone potentially help to save the life of an allergic individual

肥大细胞依赖性应激激素分泌激活的剂量可能有助于挽救过敏个体的生命

基本信息

批准号：
17607010
负责人：
MATSUMOTO Itsuro
金额：
$ 2.46万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

A large number of mast cells were found in the pars tuberalis and median eminence. When these brain mast cells were passively sensitized with immunoglobulin E via either the intracerebroventricular or intravenous route, there were marked increases in the adrenal cortisol and epinephrine secretion elicited by a subsequent antigenic challenge (whether this was delivered via the central or peripheral route). Compound48/80 (C48/80), a mast cell secretagogue, increased not only cortisol and epinephrine secretion from the adrenal glands but also increased plasma renin activity and plasma level of ADH when administered intracerebroventricularly. Resection of the bilateral splanchnic nerves below the diaphragm completely prevents the IgE-or C48/80-induced increases in PRA and epinephrine, but not increases in cortisol and ADH. Ketotifen (mast cells-stabilizing drug; given orally for 1 wk before the experiment)significantly reduced both of the IgE- and C48/80-induced increases in such humoral f … More actors. Pretreatment with anti-corticotropin-releasing factor antibodies or a histamine H^1-blocker attenuated the mast cell-dependent increases in such hormones and renin when given intracerebroventricularly. In contrast, pretreatment with a histamine H^2-blocker given intracerebroventricularly potentiated the mast celldependent increases in these substances. These data show that in the dog, degranulation of brain mast cells evokes the pituitary-adrenal and/or sympathetic-renal & adrenomedullary responses via centrally released histamine and hypothalamic corticotropin-releasing factor. On the basis of these data, we suggest that brain mast cells may act as an allergen sensor. Furthermore, we suggest that the brain mast cells-dependent increases in adrenocortical secretion and vasoactive substances could potentially help to save the life of an individual by ameliorating the effects of the not only hyper-immune reactions but also cardiovascular and respiratory dysfunction that would otherwise occur during an outbreak of type-I allergy. Less

结节部和正中隆起内可见大量肥大细胞。当这些脑肥大细胞被动致敏免疫球蛋白E通过脑室内或静脉途径，有显着增加肾上腺皮质醇和肾上腺素分泌引起的后续抗原的挑战（无论是通过中央或外周途径）。化合物48/80（C48/80）是一种肥大细胞促分泌剂，当脑室内给药时，不仅增加肾上腺皮质醇和肾上腺素的分泌，而且增加血浆肾素活性和血浆ADH水平。切除膈下双侧内脏神经可完全阻止IgE或C48/80诱导的PRA和肾上腺素升高，但不能阻止皮质醇和ADH升高。酮替芬（肥大细胞稳定药物;实验前口服1周）显著降低了IgE和C48/80诱导的这种体液因子的增加。 ...更多信息演员脑室内给予抗促肾上腺皮质激素释放因子抗体或组胺H^1受体阻滞剂预处理可减弱肥大细胞依赖性的激素和肾素升高。相反，侧脑室给予组胺H^2受体阻滞剂预处理可增强这些物质的肥大细胞依赖性增加。这些数据表明，在狗中，脑肥大细胞的脱粒通过中枢释放组胺和下丘脑促肾上腺皮质激素释放因子引起垂体-肾上腺和/或交感-肾和肾上腺髓质反应。在这些数据的基础上，我们认为，脑肥大细胞可能作为过敏原传感器。此外，我们认为，脑肥大细胞依赖的肾上腺皮质分泌和血管活性物质的增加可能有助于挽救生命的个人改善的影响，不仅超免疫反应，但心血管和呼吸功能障碍，否则会发生在爆发的I型过敏。少