New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation

用于天然产物、药物和环境污染物表征的新型对映体分离技术

• 批准号: DP0346613
• 负责人: Prof Philip Marriott
• 金额: $ 19.11万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-08-01 至 2006-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0346613
• 关键词: New; Enantiomeric; Separation; Technologies; Natural

Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicomponent characterisation of complete sample mixtures. Critical choices involve: choosing a chiral selector that interacts differentially upon all enantiomers; incorporation of selector into high-efficiency chromatographic systems; application to all target compounds in the sample. We will synthesise novel chiral selectors, incorporate these into new separation columns, apply ultra-high resolution 2-dimensional GCxGC to broad-spectrum chiral analysis of volatile chemical samples.

对映体表征允许评价潜在有害成分的药物纯度，保护消费者免受精油和天然材料的掺假，以及研究生物化学/环境系统中的化学相互作用。色谱技术（GC，HPLC和CE）的对映体分离是可用的，但限制阻止完整的样品混合物的多组分表征。关键的选择包括：选择对所有对映体有差异相互作用的手性选择剂;将选择剂并入高效色谱系统;应用于样品中的所有目标化合物。我们将合成新型的手性选择剂，将其结合到新的分离柱中，将超高分辨率二维GCxGC应用于挥发性化学样品的广谱手性分析。