Gas chromatography: separating inseparables, identifiying unidentifiables

气相色谱法：分离不可分离的物质，识别不可识别的物质

• 批准号: LE180100180
• 负责人: Prof Philip Marriott
• 金额: $ 19.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE180100180
• 关键词: Gas; chromatography; separating; inseparables; identifiying

This project aims to provide researchers with an integrated capability for separation, isolation, and precise structural identification of volatile compounds. It expects to deliver a systematic solution using unprecedented, automated multidimensional gas chromatographic separation, isolating pure compounds for off-line characterisation using appropriate spectroscopic tools, for example nuclear magnetic resonance. This will provide significant benefits, such as permitting traceability of (bio)-synthetic pathways, better characterise chemical signalling in plants, accelerate identification of advanced intermediates required for total synthesis of alkaloids, improve detection of metabolites, and determine interactions between small allergens and proteins.

该项目旨在为研究人员提供分离，分离和精确鉴定挥发性化合物结构的综合能力。它期望提供一个系统的解决方案，使用前所未有的自动多维气相色谱分离，分离纯化合物，使用适当的光谱工具进行离线表征，例如核磁共振。这将提供显著的益处，例如允许（生物）合成途径的可追溯性，植物中更好的生物化学信号传导，加速生物碱总合成所需的高级中间体的鉴定，改善代谢物的检测，并确定小过敏原和蛋白质之间的相互作用。