Behavioral and endocrinological analysis of stress effects on the feeding

应激对摄食影响的行为和内分泌学分析

• 批准号: 18500630
• 负责人: KIMOTO Mari
• 金额: $ 2.52万
• 依托单位: Japan Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500630/
• 关键词: gravity; stress; feeding; food efficiency; orchidectomy; ovariectomy; corticosterone; leptin; 飼料摂取; 飼料効率; 精巣; 卵巣; レプチン; 摂食行動; 内分泌; 性差; 体重; 金網拘束; ラット

The aim of this study was to clarify the effects of gravitational stress on the feeding behavior and endocrinological level of corticosterone and leptin. New findings were as follows: Stress magnitude. Male Wistar albino rats (39-69 days after birth) received +0.6,+1.0 and +1.4G showed decrease in increase pattern of body weight. Food intake per body weight was decreased in +1.0 and +1.4G loadings, and food efficiency was smaller in rats which received gravity stress. Corticosteron level was significantly increased after gravity loading. These results suggest that gravity stress had critical influences on the feeding behavior and body weight. Gender diarence orchidectomy experiment; Rats with orchidectomy received +1.0G gravity stress during 30 days (63-92 days after birth). Body weight of orchidectomized rats was decreased as compared with that of intact rats. After gravity loading, body weight was decreased in both intact and orchidectomized rats, especially body loss appeared early … More in orchidectomized rats. In addition food intake volume per body weight was clearly observed in orchidectomized rats. However, no differences of food efficieny were detected between intact and orchidoectomized rats. Corticosterone level was higher after gravity loading both in intact and orchidoectomized rats, but, leptin level was not changed. Oyariectomy experiment; Body weight of ovariectomized rats was more increased than that of intact rats 14 days after ovariectomy. After gravity loading, decrease in increasing pattern of body weight was observed in ovariectomized rats, but, this was not in intact female rats. As compared with intact rats, food intake volume in ovariectomized rats was decreased just after ovariectomy, however, it was increased 12 to 21 days after ovariectomy. Food efficiency was increased 11 to 20 days after ovariectomyThe present results showed that sex hormone has protective or resistance effects on the stress, and that female hormone is more powewrful against stress. Less

本研究旨在阐明重力应激对摄食行为及皮质酮和瘦素内分泌水平的影响。新发现如下：应力大小。雄性Wistar白化大鼠（出生后39 ~ 69 d）给予+0.6、+1.0和+1.4G，体重增加呈下降趋势。在+1.0 g和+1.4G负荷下，大鼠的单位体重摄食量降低，食物效率降低。重力负荷后皮质酮水平显著升高。这些结果表明，重力应力对摄食行为和体重有重要影响。性别差异的兰花切除术实验；切除睾丸的大鼠在30天（出生后63 ~ 92天）内接受+1.0G重力应激。与正常大鼠相比，去兰大鼠的体重有所下降。重力负荷后，正常大鼠和去兰科大鼠的体重均有所下降，其中去兰科大鼠的体重下降更早。此外，在去兰大鼠中可以清楚地观察到每体重的食物摄取量。然而，在完整的大鼠和切除的大鼠之间没有发现食物效率的差异。正常大鼠和去兰大鼠重力负荷后皮质酮水平均升高，而瘦素水平无明显变化。Oyariectomy实验;切除卵巢的大鼠体重在术后14天明显高于未切除卵巢的大鼠。在重力负荷作用下，去卵巢大鼠的体重增加规律有所下降，而未受影响的雌性大鼠则没有这种变化。与未切除卵巢的大鼠相比，切除卵巢后大鼠的食物摄取量在刚切除卵巢时减少，但在切除卵巢后12 ~ 21天食量增加。结果表明，性激素对应激具有保护或抵抗作用，而雌性激素对应激的抵抗作用更强。少

项目成果

New Anatomy and Physiology

新解剖学和生理学

• 发表时间: 2007
• 作者: Toda K;Kimoto M
• 通讯作者: Kimoto M

Effects of stress applied at the late stage of pregnancy on the feeding behavior in the rat.

妊娠后期应激对大鼠摄食行为的影响。

• 发表时间: 2007
• 期刊: Cell Stress & Chaperons 12
• 作者: Kimoto M.;Amano R.;Ishikawa R.;Ooe Y.;Shimura M.;Nimuma K..;Hirakawa H.;Kumei Y.;Toda K
• 通讯作者: Toda K

新解剖生理学

新的解剖学和生理学

• 发表时间: 2007
• 作者: 戸田 一雄;木本 万里
• 通讯作者: 木本 万里

Effects of stress applied at the late stage of pregnancy on the feeding behavior in the rat

妊娠后期应激对大鼠摄食行为的影响

• 发表时间: 2007
• 期刊: Cell Stress&Chaperons 12
• 作者: Kimoto M.;Amano R.;Ishikawa R.;Ooe Y.;Shimura M.;Niinuma K.;Hirakawa H.;Kumei Y.;Toda K
• 通讯作者: Toda K

Neuronal activities in rat hippocampus at altered gravity and 5HT modulation

改变重力和 5HT 调制时大鼠海马的神经元活动

• 发表时间: 2007
• 作者: Kumei Y.;Zeredo JL.;Ikeda T.;Suzuki H.;Kimoto M.;Toda K
• 通讯作者: Toda K