Development of self-organized materials using anion-controllable interaction

利用阴离子可控相互作用开发自组织材料

基本信息

批准号：
18550116
负责人：
KUBO Yuji
金额：
$ 2.68万
依托单位：
Saitama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

We briefly summarized the research on the title. 1) Self-organized anion sensors with alizarins as a reporter As our on-going project for developing chemosensors for the detection of chemically and biologically important anions, we synthesized several phenylboronic acid derivatives which act as a receptor moiety. The combination of it with catecholcontained alizarins as a reporter unit allows us to propose self-organized sensor systems. A self-organized fluorescent sensor consisting of alizarin and o-aminomethylphenylboronic acid shows a highly selective fluoride ion-response in H_2O-MeOH (1: 4 w/w) at pH 5.5. On another front, Zn^<II>-DPA (DPA = dipicolylamine)-appended phenylboronic acid forms an assembly with alizarin-dye under neutral conditions. Addition of pyrophosphate (Ppi) causes reorganization of the complex to produce an alternative boronate ester assembly and caused an increase in fluorescence. The related bis (Zn^<II>-DPA)-appended phenylboronic acid - ARS (alizarin red S) ensemble exhibited a selective response for phytate. 2) Ion-pair driven molecular capsule Taken advantage of reversible boronate esterification we have developed the ion pair-driven heterodimeric capsule formation of a cyclotricatechylene 1 and a boronic acid-appended hexahomotrioxacalix [3] arene 2. Although 1 does not interact with 2 in a protic solution, in the presence of Et4NAcO quantitative formation of a heterodimeric capsule via boronate esterification was observed in the NMR containing ^1H, ^1H ROESY and DOSY, a direct result of anion-induced boronate ester formation and the Et_4N^+ template. Reversible boronate esterification allowed us to selectively control capsule assembly using pH switching.

我们简要总结了标题的研究。 1）自组织的阴离子传感器以艾他素为记者，作为我们正在进行的化学传感器进行化学和生物学上重要的阴离子的持续项目，我们合成了几种充当受体部分的苯基晶型烷酸衍生物。它与Catecholcontained Alizarins作为记者单元的组合使我们能够提出自组织的传感器系统。一个由α和氨基甲基苯基 - 苯基 - 纤维酸组成的自组织的荧光传感器在pH 5.5时在H_2O-MEOH（1：4 w/w）中显示出高度选择性的氟离子反应。在另一个方面，Zn^<ii> -DPA（DPA =二甲基胺） - 在中性条件下与αArizarin-dye形成一个组件。焦磷酸盐（PPI）的添加导致复合物的重组，以产生替代的富富酯组件，并导致荧光增加。相关的bis（Zn^<ii> -dpa） - 涂抹苯基酸 - ARS（alizarin red s）合奏表现出对植酸的选择性响应。 2）离子-PAIR驱动的分子胶囊利用可逆的硼酸酯酯化优势，我们开发了离子配对驱动的杂二聚体胶囊的形成，其环形甲基烯1和硼酸施加的hoxahomotrioxacalix [3] Arene 2。在包含 ^1H， ^1H rosy和dosy的NMR中观察到异二聚体胶囊，这是阴离子诱导的硼酸酯形成和ET_4N ^+模板的直接结果。可逆的硼酸酯酯化使我们能够使用pH开关选择性地控制胶囊组件。