Broader understanding of the transduction mechanisms in insect sugar receptors : Asignal transduction pathway involving nitric oxide

更广泛地了解昆虫糖受体的转导机制：涉及一氧化氮的信号转导途径

• 批准号: 18570068
• 负责人: NAKAMURA Tadashi
• 金额: $ 2.7万
• 依托单位: The University of Electro-Communications
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18570068/
• 关键词: 昆虫; 糖受容細胞; 苦味物質受容細胞; 情報変換機構; 一酸化窒素; 環状ヌクレオチド; 食欲調節機構; 吻伸展反射; ショウジョウバエ; アポトーシス遺伝子; クロキンバエ; 苦味受容細胞; GAL4; UASシステム; 動物生理; 化学; セカンドメッセンジャー; 化学感覚

Relationships between NO-production and the excitation mechanisms in the taste cells and between the taste sensation and appetite regulation were investigated. NO-sensitive guanylyl cyclase (sGC) was detected and suggested to participate in the signal transduction pathways in the sugar cells, while other pathway was detected in the bitterness cells. Meanwhile it was demonstrated that the fly's aversive behavior to sucrose after their feeding sucrose in the limonene fume was due to the formation of long-term memory.

研究了NO的产生与味觉细胞兴奋机制的关系以及味觉与食欲调节的关系。检测到NO敏感的鸟苷酸环化酶（sGC）参与了糖细胞中的信号转导途径，而苦味细胞中检测到其他信号转导途径。同时也证明了在柠檬烯烟雾中取食蔗糖后果蝇对蔗糖的厌恶行为是由于长时程记忆的形成。

项目成果

Contribution of inositol 1, 4, 5-trisphosphate transduction cascade to the detection of "bitter" compound in blowflys

肌醇 1,4,5-三磷酸转导级联对检测苍蝇中“苦味”化合物的贡献

• 发表时间: 2009
• 期刊: Comparative Biochemistry and Physiology Part A,(電子版) (doi : 10.1016/j.cbpa.2009.03.004)
• 作者: Ouyang Q;Sato H;Murata Y;Nakamura A;Ozaki M;Nakamura T
• 通讯作者: Nakamura T

クロキンバエ中枢神経系における摂食調節機能へのAMPKの関与

AMPK 参与黑蝇中枢神经系统摄食调节

• 发表时间: 2009
• 作者: Nakamura A;Suzuki T;Taniguchi D;Matsuda A;Tobeta M;Nakamura T;米本聖夜子;瀬戸美星;中村整
• 通讯作者: 中村整

Chemosensory regulation of feeding in the blowfly : several studies after ‘The Hungly Fly'(SEB Experimental Biology Series Vol 63. Insect Taste, Chapter 4)

绿头苍蝇摄食的化学感应调节：《饥饿的苍蝇》之后的几项研究（SEB 实验生物学系列第 63 卷。昆虫味觉，第 4 章）

• 发表时间: 2009
• 作者: Ozaki;Mamiko
• 通讯作者: Mamiko

NO-cGMP signaling pathway in sugar receptor neurons in the blowfly in "Frontiers in Molecular Endocrinology of Invertebrates and Vertebrates, Vol.2"

《无脊椎动物和脊椎动物分子内分泌学前沿，第 2 卷》中苍蝇糖受体神经元中的 NO-cGMP 信号通路

• 发表时间: 2007
• 作者: Ozaki;Mamiko;中村整;Tadashi Nakamura
• 通讯作者: Tadashi Nakamura

Odour of limonene affects feeding behavior in the blowfly, Phormiaregina.

柠檬烯的气味会影响绿头蝇（Phormiaregina）的摄食行为。

• 发表时间: 2008
• 期刊: Neuroscience Letters 446
• 作者: Nakamura;Atsushi
• 通讯作者: Atsushi