The effect of hypertonic saline solution on vasodilatation of superior sagittal sinus using magnetic resonance imaging in normovolenmic dogs

磁共振成像研究高渗盐水溶液对正常血容量犬上矢状窦血管舒张的影响

• 批准号: 18580319
• 负责人: SUZUKI Kazuyuki
• 金额: $ 1.89万
• 依托单位: Rakuno Gakuen University (2007)Nihon University (2006)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18580319/
• 关键词: Hypertonic saline solution; Mannitol; Dextran; Superior sagittal sinus; Cerebrospinal fluid; Canine; Maanetic resonance imaain; Echocardiograph; 犬; 脳血液循環; 磁気共鳴装置; 脳血流速度; 脳血流量; 獣医学; 外科; 循環器・高血圧; 脳・神経; 薬理学; 高張食塩

Several animal studies have demonstrated the beneficial effects of hypertonic saline (HSS) on cerebral blood flow, intracranial pressure and brain water content. This study aimed to investigate, using magnetic resonance imaging, (1) whether a small volume of HSS is superior to dextran in vasodilatation of cerebral vessels and reduction of cerebrospinal fluids in dogs, and (2) whether a small volume of 7.2% hypertonic saline solution with 6% dextran 70 (HSD) is superior to mannitol in vasodilatation of encephalic vessels in the dogs.STUDY 1 : HSS induced significant expansion of the cross-section of superior sugittal sinus at the vertical section of pituitary and a decrease in cerebrospinal fluid area at the vertical section of epencephalic limbic more than dextran 40 did. However, the relative plasma volume in the dog received dextran 40 was significantly higher after t=30 min than the HSS group (p<0.001). Therefore, it is suggested that HSS might be superior to colloid solution in improving of cerebral circulation, whereas dextran 40 is superior to HSS in expanding systemic circulation in dogs.STUDY 2: The dogs were assigned to receive 5 mL/kg of isotonic saline solution (ISS) as control, 20% mannitol or HSD infusion at a flow rate of 20 mL/kg/hours via right cephalic vein. Venous blood samples were collected immediately before fluid infusion (pre) and every 15 minutes until 120 minutes after the initiation of fluid infusion. Immediately after collection of each blood sample, T1 and T2-weighted magnetic resonance imaging recordings were undergone. Immediately after HSD infusion, the area of the cross-section of superior sagittal sinus was significantly greater than that of beagles in the other groups (p<0.001), reaching the 2.09±0.25 times pre-value. Therefore, it is suggested that 5 mL/kg of HSD might be superior to isovolume of mannitol in reducing CSF in the dog.

一些动物研究已经证明了高渗盐水（HSS）对脑血流量、颅内压和脑含水量的有益作用。本研究旨在通过磁共振成像研究(1)小体积HSS对犬脑血管的血管扩张和脑脊液的减少是否优于葡聚糖，(2)小体积7.2%高渗盐水溶液加6%葡聚糖70 （HSD）对犬脑血管的血管扩张是否优于甘露醇。研究1:HSS比右旋糖酐40更能引起垂体纵切面上矢状窦横切面明显扩大，并使附脑边缘纵切面脑脊液面积减少。然而，在t=30 min后，接受葡聚糖40治疗的狗的相对血浆体积显著高于HSS组（p<0.001）。因此，HSS可能在改善狗的脑循环方面优于胶体溶液，而葡聚糖40在扩大狗的体循环方面优于HSS。研究2：犬被分配接受5 mL/kg等渗生理盐水溶液（ISS）作为对照，20%甘露醇或HSD以20 mL/kg/小时的流速通过右头静脉输注。在输液前（预）立即采集静脉血，每15分钟采集一次静脉血，直至开始输液后120分钟。每次采血后立即进行T1和t2加权磁共振成像记录。注射HSD后，上矢状窦横切面面积显著大于其他各组（p<0.001），达到预值的2.09±0.25倍。因此，提示5ml /kg的HSD在降低狗脑脊液方面可能优于等体积甘露醇。

项目成果

The effect of hypertonic saline solution on vasodilatation of superior sagittal sinus using magnetic resonance imaging in normovolenmic dogs

磁共振成像研究高渗盐水溶液对正常血容量犬上矢状窦血管舒张的影响

• 发表时间: 2008
• 期刊: Research in Veterinary Science 84(3)
• 作者: Suzuki K;Koie H;Matsumoto T;Asano R.
• 通讯作者: Asano R.

The effect of 7.2% hypertonic saline solution on M-mode echocardiographic indices in normovolemic dogs.

%20效果%20%207.2%%20高渗%20生理盐水%20溶液%20对%20M模式%20超声心动图%20指数%20in%20正常血量%20狗。

• 发表时间: 2006
• 期刊: Journal of Veterinary Medical Sciences 68(7)予定(In print)
• 作者: Suzuki K;Aoyagi S;Koie H;Asano R.
• 通讯作者: Asano R.

The Effect of 7.2% Hypertonic Saline Solution with 6% Dextran 70 on Cardiac Contractility as Observed by an Echoocardiography in Normovolemic and Anesthetized Dogs

%20Effect%20of%207.2%%20高渗%20盐水%20溶液%20与%206%%20葡聚糖%2070%20on%20心脏%20收缩性%20as%20观察%20by%20an%20超声心动图%20in%20常容%20和%20麻醉tized%20狗

• 发表时间: 2008
• 期刊: Journal of veterinary Medical Science 70(1)
• 作者: Suzuki K;Otake M;Saida Y;Koie H;Asano R.
• 通讯作者: Asano R.

The Effect of 7.2% Hypertonic Saline Solution with 6% Dextran 70 0n Cardiac Contractlity as Observed by an Echoocardiography in Normovolemic and Anesthetized Dogs

%207.2%%20高渗%20盐水%20溶液%20与%206%%20右旋糖酐%2070%200n%20心脏%20收缩性%20as%20观察%20by%20an%20超声心动图%20in%20正常血量%20和%20A的%20效果%20嵌套%20只狗

• 发表时间: 2008
• 期刊: Joumal of Veterinary Medical Sciences 70(1)
• 作者: Suzuki K^*;Otake M;Saida Y;Koie H;Asano R.
• 通讯作者: Asano R.

Relationship between depression score and acid-base status in Japanese black calves with diarrhea

• DOI: 10.1292/jvms.69.549
• 发表时间: 2007-05-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Nakagawa, Mitsuhide;Suzuki, Kazuyuki;Taguchi, Kiyoshi
• 通讯作者: Taguchi, Kiyoshi