Study on pathophysiological and image diagnostic evaluations in calves with Bovine Respiratory Disease Complex.

牛呼吸道疾病综合征犊牛病理生理及影像诊断评价研究。

• 批准号: 21580393
• 负责人: SUZUKI Kazuyuki
• 金额: $ 3.08万
• 依托单位: Rakuno Gakuen University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21580393/
• 关键词: 牛; 気管支鏡; 高張食塩液; 呼吸器疾患; 肺炎起因菌; エンドトキシン; Mycoplasma; 肺胞洗浄液; 微量元素; アミノ酸

Bovine Respiratory Disease Complex (BRDC) is an important cause of calf pneumonia worldwide. The present studies were to evaluate the clinical pharmacological effects of Hypertonic Saline Solution (HSS) and Hypertonic Saline Dextran (HSD), and to evaluate the pathophysiological and image diagnostically findings of BRDC. Research results of these studies are as follows.(1) HSD was superior in cerebral circulation improvement effects to 20% mannitol. Therefore, HSD may be expected as anti brain hypotensive drugs.(2) the experimentally endotoxin model that was matched the clinical symptoms and plasma endotoxin activity was developed.(3) Fischer ratio of Calves with Mycoplasma pneumonia was significantly lower than the healthy calves.(4) Amount of Zn and Ca of BALF obtained from calf with BRDC was larger than healthy calf. Also, Zn/Cu ration of calves with BRDC was higher Zn/Cu ration compared with healthy one. Diagnostic cut-off value in Zn/Cu is 8.676 (p(5) The BRDC severe cases that Mycoplasma infection; endotoxin has increased in the bronchus and trachea. Those endotoxins transferred to plasma from trachea.(6) Monitoring of plasma endotoxin activity was useful to determine the therapeutic effect and prognosis coliform mastitis. Theses results obtained from this project research contributed to the pathogenesis of BRDC.

牛呼吸道疾病综合征（BRDC）是世界范围内引起犊牛肺炎的重要原因。本研究旨在评价高渗盐溶液（HSS）和高渗盐右旋糖酐（HSD）的临床药理作用，并评价BRDC的病理生理学和影像学表现。这些研究的研究结果如下。(1)HSD改善脑循环的作用上级20%甘露醇。因此，HSD有望成为抗脑水肿药物。(2)建立了与临床症状和血浆内毒素活性相匹配的实验性内毒素模型。(3)肺炎支原体感染犊牛的Fischer氏比率显著低于健康犊牛。(4)BALF中锌、钙含量均高于健康犊牛。患BRDC犊牛的Zn/Cu比高于健康犊牛。Zn/Cu的诊断临界值为8.676（p（5）支气管和气管支原体感染、内毒素增加的BRDC重度病例。这些内毒素从气管转移到血浆中。(6)检测血浆内毒素活性有助于判断大肠杆菌性乳腺炎的疗效和预后。本课题的研究结果对BRDC的发病机制做出了贡献。

项目成果

牛医療におけるエンドトキシン関連性疾患とPTSTMによる予後診断の可能性.

牛医学中的内毒素相关疾病和 PTSTM 的预后潜力。

• 作者: Yamada O;Kobayashi M;Sugisaki O;Ishii N;Ito K;Kuroki S;Sasaki Y;Isotani M;Ono K;Washizu T;Bonkobara M.;鈴木一由
• 通讯作者: 鈴木一由

Comparison of the Alkalizing Effects of Bicarbonate Precursors in Calves with Experimentally Induced Metabolic Acidosis

碳酸氢盐前体对实验性代谢性酸中毒犊牛的碱化作用比较

• 发表时间: 2009
• 期刊: J. Vet. Med. Sci
• 作者: Nakagawa M;Suzuki K;Takahashi F;Kamikatano K;Koiwa M;Taguchi K
• 通讯作者: Taguchi K

エンドトキシンチャレンジ子牛を用いたCow-Side Portable Test Systemによる血清中エンドトキシン活性値測定法の評価

使用内毒素挑战犊牛的牛侧便携式测试系统评估血清内毒素活性测量方法

• 发表时间: 2012
• 作者: 嶋守俊雄;赤坂 遼;真田慶之助;土谷正和; Lakritz Jeffrey;田村 豊;小岩政照;鈴木一由
• 通讯作者: 鈴木一由