Study on pathophysiological and image diagnostic evaluations in calves with Bovine Respiratory Disease Complex.

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Bovine Respiratory Disease Complex (BRDC) is an important cause of calf pneumonia worldwide. The present studies were to evaluate the clinical pharmacological effects of Hypertonic Saline Solution (HSS) and Hypertonic Saline Dextran (HSD), and to evaluate the pathophysiological and image diagnostically findings of BRDC. Research results of these studies are as follows.(1) HSD was superior in cerebral circulation improvement effects to 20% mannitol. Therefore, HSD may be expected as anti brain hypotensive drugs.(2) the experimentally endotoxin model that was matched the clinical symptoms and plasma endotoxin activity was developed.(3) Fischer ratio of Calves with Mycoplasma pneumonia was significantly lower than the healthy calves.(4) Amount of Zn and Ca of BALF obtained from calf with BRDC was larger than healthy calf. Also, Zn/Cu ration of calves with BRDC was higher Zn/Cu ration compared with healthy one. Diagnostic cut-off value in Zn/Cu is 8.676 (p(5) The BRDC severe cases that Mycoplasma infection; endotoxin has increased in the bronchus and trachea. Those endotoxins transferred to plasma from trachea.(6) Monitoring of plasma endotoxin activity was useful to determine the therapeutic effect and prognosis coliform mastitis. Theses results obtained from this project research contributed to the pathogenesis of BRDC.