Estblishment of curative therapy for Alzheimer's disease with Humanin peptides

护脑肽治疗阿尔茨海默病的方法的建立

• 批准号: 18590106
• 负责人: HASHIMOTO Yuichi
• 金额: $ 2.57万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590106/
• 关键词: Alzheimer's disease; neurocnal cell death; Humanin; cytokine; receptor; STAT3; small comoound; Transforming Growth Factor β

In this research term, we focused on the identification of Humanin (HN) receptor and the search for small compounds which have HN activity.1. Identification of HN receptorI tried to identify the receptor for Humanin (HN), which is known as a medicinal seed for development of anti-Alzheimer's disease (AD) drug, using various molecular and cell biological techniques. From the results, I found that the HN receptor was consisted of WSX-1, ciliary neurotrophioc factor receptor (CNTFR), and gp1 30 consist of receptor. In addition, a novel splicing variant of WSX-1 was identified.2. HN-like small compound searchTo apply the clinical trila for AD patients, I tried to identify. the small molecule compound search. As mentioned above, one of component of HN receptor is "gp130", in frist, we tried to identify the molecules which can (a) bind to gp130, (2) show anti-AD insults activity, (3) activate STAT3, and(4) form the "WSX-1/CNTFR/gp130" complex. Until now, I found 2 molecules.

在本研究阶段，我们主要致力于人蛋白（Humanin， HN）受体的鉴定和具有HN活性的小分子化合物的寻找。HN受体的鉴定我试图利用各种分子和细胞生物学技术鉴定人类蛋白（HN）受体，这是开发抗阿尔茨海默病（AD）药物的药用种子。从结果中，我发现HN受体由WSX-1、睫状神经营养因子受体（CNTFR）和gp1 30组成。此外，还发现了WSX-1的一个新的剪接变体。hn样小化合物搜索为了应用于AD患者的临床诊断，我试图识别。小分子化合物搜索。如上所述，HN受体的一个组成部分是“gp130”，首先，我们试图找到能够(a)结合gp130，(2)表现出抗ad损伤活性，(3)激活STAT3，(4)形成“WSX-1/CNTFR/gp130”复合物的分子。到目前为止，我找到了2个分子。

项目成果

Humanin and colivelin: Neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis

• DOI: 10.1111/j.1527-3458.2006.00113.x
• 发表时间: 2006-06-01
• 期刊: CNS DRUG REVIEWS
• 作者: Matsuoka, Masaaki;Hashimoto, Yuichi;Nishimoto, Ikuo
• 通讯作者: Nishimoto, Ikuo

Humanin inhibits neuronal death via a CNTF receptor a/WSX-1/gp 130 complex

护脑素通过 CNTF 受体 a/WSX-1/gp 130 复合物抑制神经元死亡

• 发表时间: 2007
• 作者: Yuichi;Hashimoto;Megumi;Kurita;Ikuo;Nishimoto;Sadakazu;Aiso;Masaaki;Matsuoka
• 通讯作者: Matsuoka

Humanin inhibits neuronal death via a CNTF receptor α/WSX-1/gp130 complex

护脑素通过 CNTF 受体 α/WSX-1/gp130 复合物抑制神经元死亡

• 发表时间: 2007
• 作者: S. Neya;et. al.;Yuichi Hashimoto
• 通讯作者: Yuichi Hashimoto

Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-b

转化生长因子β2自分泌介导淀粉样蛋白b诱导的神经元细胞死亡

• 发表时间: 2006
• 期刊: J Neurosci Res 83-6
• 作者: Hashimoto;Y;Nawa;M;Chiba;T;Aiso;S;Nishimoto;I;Matsuoka;M
• 通讯作者: M