Molecularpharmacological analysis of mechanosensitive cation channels in vascular endothelial cells.

利用原代培养的大鼠心肌细胞，阐明了TRPC1在心肌肥大中的调节作用。(Ohba，T等，《分子和细胞心脏病学杂志》，2007年)2)鉴定小鼠钙通道α1C(Cav1.2-a)亚基的心脏亚基及其与β2亚基的优先结合。我们描述了电压依赖性钙通道α1亚基的心肌亚基异构体，对应于兔α1C-a(Cavl.2a)的同源异构体。我们还克隆了平滑肌亚型α1C-b(Cavl.2b)和α1C-d(Cavl.2d)(Murakami，M等，分子和细胞心脏病学杂志，2006年)。

1) Functional analysis of TRPC in the cardiac hypertrophy.Using rat primary cultured cardiomyocytes, regulatory role of TRPC1 in the cardiac hypertrophy was clarified.(Ohba, T et al., Journal of Molecular and Cellular Cardiology, 2007).2) Identification of a cardiac isoform of the murine calcium channel α1C (CaV 1.2-a) subunit and its preferential binding with the β2 subunit.We describe a cardiac muscle isoform of the voltage-dependent calcium channel α1 subunit, which corresponds to the rabbit ortholog of α1C-a (Cavl.2a). We also cloned smooth muscle isoforms α1C-b (Cavl.2b) and α1C-d (Cavl.2d).(Murakami, M et al., Journal of Molecular and Cellular Cardiology, 2006).