Molecularpharmacological analysis of mechanosensitive cation channels in vascular endothelial cells.

1)TRPC在心肌肥厚中的功能分析利用原代培养的大鼠心肌细胞，阐明TRPC 1在心肌肥厚中的调节作用。(Ohba，T等人，分子和细胞心脏病学杂志，2007）。2）小鼠钙通道α1C（CaV 1.2-a）亚基的心脏同种型的鉴定及其与β2亚基的优先结合。我们描述了电压依赖性钙通道α1亚基的心肌同种型，其对应于α1C-a（CaV 1.2a）的兔直系同源物。我们还克隆了平滑肌亚型α1C-b（Cavl.2b）和α1C-d（Cavl.2d）。（Murakami，M等人，Journal of Molecular and Cellular Cardiology，2006）。

1) Functional analysis of TRPC in the cardiac hypertrophy.Using rat primary cultured cardiomyocytes, regulatory role of TRPC1 in the cardiac hypertrophy was clarified.(Ohba, T et al., Journal of Molecular and Cellular Cardiology, 2007).2) Identification of a cardiac isoform of the murine calcium channel α1C (CaV 1.2-a) subunit and its preferential binding with the β2 subunit.We describe a cardiac muscle isoform of the voltage-dependent calcium channel α1 subunit, which corresponds to the rabbit ortholog of α1C-a (Cavl.2a). We also cloned smooth muscle isoforms α1C-b (Cavl.2b) and α1C-d (Cavl.2d).(Murakami, M et al., Journal of Molecular and Cellular Cardiology, 2006).