Molecularpharmacological analysis of mechanosensitive cation channels in vascular endothelial cells.

血管内皮细胞机械敏感阳离子通道的分子药理学分析。

• 批准号: 18590230
• 负责人: IIJIMA Toshihiko
• 金额: $ 2.57万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590230/
• 关键词: TRP; smooth muscle; calcium; ion channel; hypertension; 頻脈

1) Functional analysis of TRPC in the cardiac hypertrophy.Using rat primary cultured cardiomyocytes, regulatory role of TRPC1 in the cardiac hypertrophy was clarified.(Ohba, T et al., Journal of Molecular and Cellular Cardiology, 2007).2) Identification of a cardiac isoform of the murine calcium channel α1C (CaV 1.2-a) subunit and its preferential binding with the β2 subunit.We describe a cardiac muscle isoform of the voltage-dependent calcium channel α1 subunit, which corresponds to the rabbit ortholog of α1C-a (Cavl.2a). We also cloned smooth muscle isoforms α1C-b (Cavl.2b) and α1C-d (Cavl.2d).(Murakami, M et al., Journal of Molecular and Cellular Cardiology, 2006).

1)TRPC在心肌肥厚中的功能分析利用原代培养的大鼠心肌细胞，阐明TRPC 1在心肌肥厚中的调节作用。(Ohba，T等人，分子和细胞心脏病学杂志，2007）。2）小鼠钙通道α1C（CaV 1.2-a）亚基的心脏同种型的鉴定及其与β2亚基的优先结合。我们描述了电压依赖性钙通道α1亚基的心肌同种型，其对应于α1C-a（CaV 1.2a）的兔直系同源物。我们还克隆了平滑肌亚型α1C-b（Cavl.2b）和α1C-d（Cavl.2d）。（Murakami，M等人，Journal of Molecular and Cellular Cardiology，2006）。

项目成果

Neuron-restrictive silencing factor(NRSF)is responsible for cardiac hypertrophy by regulating expression of transient receptor potential channel 1(TRPC1)

神经元限制性沉默因子 (NRSF) 通过调节瞬时受体电位通道 1 (TRPC1) 的表达导致心脏肥大

• 发表时间: 2007
• 作者: Manabu;Murakami;尾野恭一;大場貴喜
• 通讯作者: 大場貴喜

Modified behavioral characteristics following ablation of the voltage-dependent calcium channel β3 subunit

• DOI: 10.1016/j.brainres.2007.05.041
• 发表时间: 2007-07-30
• 期刊: BRAIN RESEARCH
• 影响因子: 2.9
• 作者: Murakami, Manabu;Nakagawasai, Osamu;Iijima, Toshihiko
• 通讯作者: Iijima, Toshihiko

Identification of a cardiac isoform of the murine calcium channel α1C (Cav1.2-a) subunit and its preferential binding with the β2 subunit

• DOI: 10.1016/j.yjmcc.2006.05.002
• 发表时间: 2006-07-01
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Murakami, Manabu;Ohba, Takayoshi;Iijima, Toshihiko
• 通讯作者: Iijima, Toshihiko

Modified sympathetic regulation in N-type calcium channel null-mouse

N型钙通道零鼠的交感神经调节被修饰

• 发表时间: 2007
• 期刊: Biochem Biophys Res Commun 354
• 作者: Murakami;M.;et. al.
• 通讯作者: et. al.

Regulatory role of neuron-restrictive silencing factor in the expression of TRPC 1

神经元限制性沉默因子对TRPC 1表达的调节作用

• 发表时间: 2006
• 期刊: Biochem Biophys Res Commun 351
• 作者: Ohba;T.;et. al.
• 通讯作者: et. al.