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Histopathological re-evaluation of pancreatic epithelial lesions : PanIN and IPMN

胰腺上皮病变的组织病理学重新评估：PanIN 和 IPMN

基本信息

批准号：
18590343
负责人：
SHIMIZU Michio
金额：
$ 1.54万
依托单位：
Saitama Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590343/
关键词：
PanIN IPMN Intraductal tumor Cancerization of the duct Pancreatobiliary type gastric type intestinal type pancreatobiliary type oncocvtic type elastic Masson Goldner染色 carcinoma in situ cancerization of the duct

项目摘要

We performed the histopathological re-evaluation of pancreatic epithelial lesions, especially PanIN and IPMN by using immunohistochemistry and molecular biology. Then, we tried to find the incipient lesion of IPMN and considered the possible pathway of developing pancreatic cancer from PanIN as well as IPMN. The incidence of PanIN-1 was relatively high ; however, the incidence of PanIN-3 was very rare especially in autopsy cases. We sometimes noted the coincidental PanIN-1 and PanIN-2 lesions around gastric type IPMNs. This may suggest the possible pathway of IPMN from PanIN-1 or 2. Regarding the cancerization of the duct, there were at least two types of cancerization of the ducts.Concerning IPMN subtypes, so far at least four subtypes have been proposed. These are gastric type, intestinal type, pancreatobiliary type, and oncocytic type. Reviewing these IPMN subtypes, we postulated that both pancreatobiliary type and oncocytic type were probably derived from gastric type IPMNs, and the pancreatobiliary type and oncocytic type IPMN should be regarded as high grade lesions of gastric type IPMNs. In addition, we found another type of intraductal tumor with scant mucin.From the cytological point of view, these four subtypes should be evaluated in cytology specimens since the prognosis differs according to these subtypes.

我们利用免疫组织化学和分子生物学对胰腺上皮病变，特别是 PanIN 和 IPMN 进行了组织病理学重新评估。然后，我们试图寻找IPMN的早期病变，并考虑PanIN和IPMN发展为胰腺癌的可能途径。 PanIN-1的发生率较高；然而，PanIN-3 的发生率非常罕见，尤其是在尸检病例中。我们有时注意到胃型 IPMN 周围同时存在 PanIN-1 和 PanIN-2 病变。这可能提示IPMN可能来自PanIN-1或2的途径。关于导管癌化，至少有两种类型的导管癌化。关于IPMN亚型，迄今为止至少提出了四种亚型。这些是胃型、肠型、胰胆型和嗜酸细胞型。回顾这些IPMN亚型，我们推测胰胆型和嗜酸细胞型均可能源自胃型IPMN，并且胰胆型和嗜酸细胞型IPMN应被视为胃型IPMN的高级病变。此外，我们还发现了另一种缺乏粘蛋白的导管内肿瘤。从细胞学角度来看，这四种亚型应在细胞学标本中进行评估，因为不同亚型的预后不同。