Cancerization and invasion of pancreatic neoplasm : Toward the approach for targeted therapy

胰腺肿瘤的癌化和侵袭：寻找靶向治疗方法

• 批准号: 21590403
• 负责人: SHIMIZU Michio
• 金额: $ 2.91万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590403/
• 关键词: 診断病理学; 膵腫瘍; 膵癌; ランゲルハンス島; 免疫組織化学; 浸潤様式; 扁平上皮; p63; CD44; 発育様式; 腺房; 膵管; 免疫三重染色; low-grade PanIN; gastric type IPMN; ITPN; intestinal type IPMN; pancreatic adenocarcinoma; adenocarcinoma derived from IPMN; mucinous carcinoma; MUC5AC

Most of the cases of pancreatic adenocarcinoma derived from IPMN were derived from intestinal type IPMN. As for the pattern of invasion in pancreatic carcinoma, most advanced pancreatic cancers revealed a mixed replacement pattern(interlobular replacement pattern and intralobular replacement pattern) as well as a haphazard growth pattern. Entrapped normal pancreatic structures within the area of invasive carcinoma were easily and clearly identified by using triple immunostains. The distribution or the extent of such entrapped normal cells differed depending on the cases.

大多数源自IPMN的胰腺癌病例均源自肠型IPMN。至于胰腺癌的侵袭模式，大多数晚期胰腺癌显示出混合替代模式（小叶间替代模式和小叶内替代模式）以及随意生长模式。三重免疫组化染色可清楚地识别浸润性癌区域内的正常胰腺结构。这种截留的正常细胞的分布或程度根据病例而不同。

项目成果

膵臓のPanIN病変とIPMN :その相互関係とpathwayについて

胰腺 PanIN 病变和 IPMN：它们的相互关系和途径

• 发表时间: 2009
• 作者: Yamaguchi H;Shimizu M;Ban S;Koyama I;Haroti T;Fujita I;et al;Yamaguchi H;Shimizu Y;Shimizu K;Ban S;Shimizu M;Shimizu M;Shimizu M;Shimizu M;清水道生;清水道生;清水道生
• 通讯作者: 清水道生

Pancreatic intraductal lesions with possible relationship with gastric type intraductal papillary mucinous neoplasm : pyloric gland-type intra-ductal tubular adenoma and intraductal oncocytic papillary neoplasm

与胃型导管内乳头状粘液性肿瘤可能相关的胰腺导管内病变：幽门腺型导管内管状腺瘤和导管内嗜酸细胞乳头状肿瘤

• 发表时间: 2010
• 期刊: Histopathology
• 影响因子: 6.4
• 作者: Ban S;Satoh H;Satoh M;Ishido Y;Nakayama N;Yamaguchi H;Shimizu M;Ban S
• 通讯作者: Ban S

Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas

• DOI: 10.1136/gut.2010.210567
• 发表时间: 2011-04-01
• 期刊: GUT
• 影响因子: 24.5
• 作者: Furukawa, Toru;Hatori, Takashi;Shimizu, Michio
• 通讯作者: Shimizu, Michio

Triple immunostains for assessment of invasive patterns of pancreatic carcinoma

用于评估胰腺癌侵袭模式的三重免疫染色

• 发表时间: 2011
• 作者: Yamaguchi H;Shimizu M;Ban S;Koyama I;Haroti T;Fujita I;et al;Yamaguchi H;Shimizu Y;Shimizu K;Ban S;Shimizu M
• 通讯作者: Shimizu M

Invasive ductal carcinoma of the pancreas tail with noninvasive growth through the nondilated main pancreatic duct and macroscopically cystic invasive carcinomatous glands

胰尾浸润性导管癌，通过非扩张的主胰管和宏观囊性浸润性癌腺非浸润性生长

• 发表时间: 2011
• 期刊: Ann Diagn Pathol
• 影响因子: 2
• 作者: Ban S;Satoh H;Satoh M;Ishido Y;Nakayama N;Yamaguchi H;Shimizu M
• 通讯作者: Shimizu M