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Real time diagnosis of gastric mucosa and cancer using confocal endomicroscopy

使用共焦内窥镜实时诊断胃粘膜和癌症

基本信息

批准号：
18590675
负责人：
NIWA Yasumasa
金额：
$ 2.57万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590675/
关键词：
confocal endomicroscopy gastric cancer 共焦点内視論組織型粘液形質

项目摘要

A confocal endomicroscopy that has recently been developed allows the observation of living cells in vivo, and some investigators have reported the usefulness of it, but no study has reported on it with regards to gastric cancer. The aim of this study was to assess the suitability of this system for use in the diagnosis of gastric cancer.Patients and methods: Twenty-seven patients with early gastric cancer underwent confocal endomicroscopy (EG-3870CIK, Pentax, Tokyo, Japan). After intravenous administration of fluorescein sodium, confocal images obtained from fundic mucosae, pyloric mucosae and cancerous lesions were interpreted by two pathologists independently, and compared to the histological findings including CD34 immunostaining of biopsy or resected specimens of the same sites.Results: Fluorescein yielded high-quality confocal images of gastric mucosa. Those images agreed with hematoxylin and eosin staining of transverse sections of specimens of the same sites. In the results of interpretation of two pathologists, sensitivity, specificity, and accuracy rate for the diagnosis of gastric cancer were 81.8%, 97.6%, 94.2% (pathologist A) and 90.9%, 97.6%, 96.2% (pathologist B), respectively. Accuracy rates tended to decrease if poor-image cases and unreachable cases were included.Conclusion: Confocal endomicroscopy is useful for the diagnosis of gastric cancer. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.

最近开发的共聚焦显微内镜可以观察活体细胞，一些研究人员已经报道了它的有用性，但没有研究报道它与胃癌有关。本研究的目的是评估该系统用于诊断胃癌的适用性。患者和方法：27例早期胃癌患者进行了共聚焦显微内镜（EG-3870 CIK，宾得，东京，日本）。荧光素钠静脉注射后，从胃底粘膜，幽门粘膜和癌性病变获得的共聚焦图像由两名病理学家独立解释，并比较组织学检查结果，包括CD 34免疫染色活检或切除标本的相同sites.Results：荧光素产生高质量的共聚焦图像的胃粘膜。这些图像与相同部位标本的横截面苏木精和伊红染色一致。两名病理医师判读结果中，诊断胃癌的敏感性、特异性和准确性分别为81.8%、97.6%、94.2%（病理医师A）和90.9%、97.6%、96.2%（病理医师B）。结论：共聚焦显微内镜对胃癌的诊断有一定的价值。在未来，它可能允许虚拟活检，并有助于减少不必要的活检。