Dynamic Oxygen-Enhanced MR Imaging. Development for Clinical Stage Classification of COPD and TherapeuticEffect Evaluation

动态氧增强磁共振成像。

• 批准号: 18591346
• 负责人: OHNO Yoshiharu
• 金额: $ 2.43万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591346/
• 关键词: Life science; X-ray; Pulmonary Medicine; Radiology; Magnetic Resonance; 核磁気共鳴医学; 生体生命情報学

The purpose of this study was to develop the dynamic oxygen-enhanced MR imaging for clinical stage classification and therapeutic effect evaluation in COPD subjects.Non-smoking subjects and COPD patients in our institution were included in this study. All patients were assessed ATS/ERS classification of COPD or GOLD classifications. All subjects were prospectively underwent pulmonary function test, dynamic oxygen-enhanced MR imaging, perfusion scan and/ or CT. Mean relative enhancement ratio and wash-in time on dynamic oxygen-enhanced MRI and CT-base functional lung volume on quantitative CT were computationally calculated by using our proprietary software. To compare the efficacy of dynamic oxygen-enhanced MRI and quantitative CT for pulmonary functional loss assessment, both indexes were correlated with pulmonary functional parameters. To determine the efficacy of two methods for clinical stage classification, the four clinical stage groups' mean relative enhancement ratio and CT-based functional lung volume were statistically compared. In addition, this study was also included the multicenter study for assessment of oxygen-enhanced MRI, and compared capability of oxygen-enhancement and CP-based functional lung volume in clinical stages in COPD. Correlations of both indexes with pulmonary functional parameters were significant (p<0.0001). Pulmonary functional parameters and mean relative enhancement ratio for the four clinical groups showed significant differences (p<0.05). CT-based functional lung volumes of ‘Smokers without COPD' and ‘Mild COPD' were significantly different from those for 'Moderate COPD' and 'Severe or Very Severe COPD' (p<0.05). In conclusion, dynamic oxygen-enhanced MRI is effective for pulmonary functional loss assessment and clinical stage classification of smoking-related COPD as well as quantitative CT.

本研究的目的是发展动态氧增强磁共振成像用于COPD患者的临床分期和疗效评估。本研究纳入我院非吸烟受试者和COPD患者。对所有患者进行ATS/ERS COPD分类或GOLD分类评估。所有受试者前瞻性地进行肺功能检查、动态氧增强磁共振成像、灌注扫描和/或CT。采用本公司专有软件计算动态氧增强MRI的平均相对增强比和冲洗时间以及定量CT上基于CT的功能肺体积。为了比较动态氧增强MRI与定量CT对肺功能损失评估的效果，我们将两项指标与肺功能参数进行相关性分析。为确定两种临床分期分型方法的疗效，对4个临床分期组的平均相对增强率及基于ct的功能肺体积进行统计学比较。此外，本研究还纳入了氧增强MRI评估的多中心研究，并比较了氧增强和基于cp的肺功能容积在COPD临床分期中的能力。两项指标与肺功能参数的相关性均有统计学意义（p<0.0001）。四组患者肺功能参数及平均相对增强率差异均有统计学意义（p<0.05）。“无COPD吸烟者”和“轻度COPD吸烟者”的ct肺功能容量与“中度COPD吸烟者”和“重度或极重度COPD吸烟者”的ct肺功能容量差异有统计学意义（p<0.05）。综上所述，动态氧增强MRI可有效评估吸烟相关性COPD肺功能损失和临床分期，也可用于定量CT。

项目成果

Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography: Multicenter Study for Clinical Stage Classification of Smoking-related Chronic Obstructive Pulmonary Diseasa

氧增强磁共振成像与计算机断层扫描：吸烟相关慢性阻塞性肺疾病临床分期分类的多中心研究

• 发表时间: 2008
• 期刊: American Journal of Respiratory Critical Care Medicine (in press)
• 作者: Ohno;Y;Koyama;H;Nogami;M;Takenaka;D. Matsumoto;S.;Ohara;Sugimura;K;木村浩彦;大野良治
• 通讯作者: 大野良治

Dynamic Oxygen-enhanced MR Imaging vs. Quantitative CT: Capability of Pulmonary Functional Loss Assessment and Clinical Stage Classification in Smoking-related COPD Subjects

动态氧增强 MR 成像与定量 CT：吸烟相关 COPD 受试者肺功能丧失评估和临床分期分类的能力

• 发表时间: 2007
• 作者: Ohno Y;Koyoma H;Nogami M;Takenaka D;Yoshikawa T;Sugimura K.
• 通讯作者: Sugimura K.

Multicenter Trial for Pulmonary Functional Loss Assessment and Clinical Stage Classification of Smoking-related COPD in Asia: Oxygen-enhanced MRI vs. Quantitative CT

亚洲吸烟相关慢性阻塞性肺病的肺功能丧失评估和临床分期分类的多中心试验：氧增强 MRI 与定量 CT

• 发表时间: 2007
• 作者: 木村浩彦;豊岡麻理子;土田龍郎;岡沢秀彦;新井良和;椛沢宏之;松田豪;大野良治
• 通讯作者: 大野良治

Oxygen-enhanced MR Imaging vs. Quantitative CT: Capability of Pulmonary Functional Loss Assessment and Clinical Stage Classification in Smoking-related COPD Subjects

氧增强 MR 成像与定量 CT：吸烟相关 COPD 受试者肺功能丧失评估和临床分期分类的能力

• 发表时间: 2007
• 作者: Ohno;Y;Koyama;H;Nogami;M;Takenaka;D.;Yoshikawa;T;Snaimnra;K.;Dynamic
• 通讯作者: Dynamic

Multicenter Trial for Pulmonary Functional Loss Assessment and Clinical Stage Classification of Smoking-related COPD in Asia: Oxygen-enhanced MPI vs. Quantitative CT

亚洲吸烟相关慢性阻塞性肺病的肺功能丧失评估和临床分期分类的多中心试验：氧增强 MPI 与定量 CT

• 发表时间: 2007
• 作者: Ohno Y;Iwasawa T;Seo JB;Koyama H;Takahashi H;Oh Y;Nishimura Y;Sugimura K
• 通讯作者: Sugimura K