Control and alteration of mitochondrial protein traffic

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To understand the mechanisms of the functions of mitochondrial protein translocators, which control the traffic of mitochondrial proteins, we have discovered a new maintenance factor Tam41, revealed the cooperation of receptors Tom20 and Tom22 in recognition of mitochondrial targeting signals, revealed the cooperation of translocators, the TOM40 complex and TIM23 complex, in transfer of mitochondrial precursor proteins, determined the high-resolution structure of the import motor assistant protein Tim15, analyzed the competition between the sorting signals for the outer membrane and matrix/inner membrane, achieved the interaction mapping of the outer membrane translocator subunit Tom22, and altered the signal recognition functions of the receptor Tom20.