Histological analysis of brain injury with two-photon microscopy

双光子显微镜对脑损伤的组织学分析

• 批准号: 18300121
• 负责人: MIZOGUCHI Akira
• 金额: $ 9.71万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18300121/
• 关键词: Stroke; Thrombosis; Glia cells; Two photon microscopy; GFP Green mouse; Synapse formation; Cell Adhesion; Wiring Specificity

We have succeeded in rescuing placental dysplasia caused by deletion of genes, Est2, Mapk14, and Mapkl through placenta-specific gene transfer (Nature Biotechnol). We have also demonstrated that a prototype cadherin, Arcadrin, is involved in control of dendritic spine number (Neuron). By aggregation assav, we have shown hemophilic cell adhesion activity mediated by water channel aquaporin 4.1

我们已经成功地通过胎盘特异性基因转移（Nature Biotechnol）挽救了由基因Est 2、Mapk14和Mapkl缺失引起的胎盘发育不良。我们还证明了一个原型钙粘蛋白，Arcadrin，参与控制树突棘数（神经元）。通过聚集试验，我们发现了由水通道蛋白4.1介导的血友病细胞粘附活性

项目成果

Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart

• DOI: 10.1016/j.cellsig.2005.11.001
• 发表时间: 2006-09-01
• 期刊: CELLULAR SIGNALLING
• 影响因子: 4.8
• 作者: Okamoto, Ryuji;Kato, Takaaki;Ito, Masaaki
• 通讯作者: Ito, Masaaki

Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release

• DOI: 10.1523/jneurosci.2279-06.2007
• 发表时间: 2007-03-07
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Sadakata, Tetsushi;Kakegawa, Wataru;Furuichi, Teiichi
• 通讯作者: Furuichi, Teiichi

Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent Rho A activation in dendrites.

突触支架分子 α 是介导树突中 N-甲基-D-天冬氨酸受体依赖性 Rho A 激活的支架。

• 发表时间: 2007
• 期刊: Mol. Biol. Cell 27
• 作者: Iida;J.;et. al.
• 通讯作者: et. al.

Choroid plexus ependyrmal cells host neural progenitor cells in the rat

大鼠脉络丛室管膜细胞宿主神经祖细胞

• 发表时间: 2006
• 期刊: Glia 53
• 作者: Itokazu;Y.;et. al.
• 通讯作者: et. al.

Establishment of cell polarity by afadin during the formation of embryoid bodies

• DOI: 10.1111/j.1365-2443.2007.01150.x
• 发表时间: 2008-01-01
• 期刊: GENES TO CELLS
• 影响因子: 2.1
• 作者: Komura, Hitomi;Ogita, Hisakazu;Takai, Yoshimi
• 通讯作者: Takai, Yoshimi